CAJ | 학술논문

目的：探讨细胞因子在慢性牙周炎（CP）患者龈沟液（GCF）中的含量变化及相关性。方法选取我院就诊的43例慢性牙周病患者的68颗患牙，按照牙周病活动期和静止期诊断标准分为两组，另外以20颗健康成人牙设为对照组，分别收集每颗牙的龈沟液测量细胞因子IL-1、IL-2β、IL-6、TNF-α含量进行对比研究。结果 IL-1、IL-6、TNF-α在活动期患者龈沟液中含量均较对照组明显升高，而 IL-2β在活动期患者 GCF 中含量降低。经治疗转入静止期后，各观测值恢复到与对照组接近水平。结论在慢性牙周病的发生发展过程中，众多细胞因子在其中发挥了重要的作用。对CP患者采取一定的干预措施调节细胞因子的含量，效果明显。
목적：탐토세포인자재만성아주염（CP）환자간구액（GCF）중적함량변화급상관성。방법선취아원취진적43례만성아주병환자적68과환아，안조아주병활동기화정지기진단표준분위량조，령외이20과건강성인아설위대조조，분별수집매과아적간구액측량세포인자IL-1、IL-2β、IL-6、TNF-α함량진행대비연구。결과 IL-1、IL-6、TNF-α재활동기환자간구액중함량균교대조조명현승고，이 IL-2β재활동기환자 GCF 중함량강저。경치료전입정지기후，각관측치회복도여대조조접근수평。결론재만성아주병적발생발전과정중，음다세포인자재기중발휘료중요적작용。대CP환자채취일정적간예조시조절세포인자적함량，효과명현。
Objective To study the cytokines in patients with chronic periodontal disease(CP) gum liquid(GCF) content of change and correlation.Methods Select 43 patients with chronic periodontal disease in our hospital in 68 with teeth,according to the periodontal disease activity and resting stage diagnostic criteria are divided into two groups, in addition to 20 healthy adult tooth set as control group,respectively,to colect each tooth gum groove liquid measuring cytokine IL-1,2 beta,IL-6,IL - content of TNF alpha.Results IL-6,IL-1 TNF alpha gingival sulcus liquid levels in patients with activity were significantly higher than control group,the content of IL-2 beta in GCF patients with activity.After treatment into stationary phase,the observed value close to restore to the normal group.Conclusion In the process of the development of chronic periodontal disease,many cytokines play an important role in it.Take some interventions in patients with CP to adjust the content of cytokines,The efect is obvious.