CAJ | 학술논문

目的：评价5-氟尿嘧啶联合亚叶酸钙（5-FU/LV）对比5-氟尿嘧啶联合亚叶酸钙与奥沙利铂（ FOLFOX4）化疗方案治疗晚期结直肠癌患者的临床疗效及安全性。方法对我院治疗的99例晚期结直肠癌患者进行回顾性分析，其中45例患者接受了5-FU/LV化疗方案，54例接受了FOLFOX4方案，比较2组患者临床疗效及化疗不良反应。结果 FOLFOX4组客观缓解率（ ORR ）为50.0％，显著高于5-FU/LV组（28.9％）（ P＜0.05）。5-FU/LV与FOLFOX4方案不良反应主要为粒细胞减少和胃肠道不良反应，2组患者Ⅲ～Ⅳ不良反应发生率差异无统计学意义（ P＞0.05）。结论 FOLFOX4方案治疗晚期结直肠癌客观缓解率较高，且不良反应发生率与5-FU/LV方案无明显差异。
목적：평개5-불뇨밀정연합아협산개（5-FU/LV）대비5-불뇨밀정연합아협산개여오사리박（ FOLFOX4）화료방안치료만기결직장암환자적림상료효급안전성。방법대아원치료적99례만기결직장암환자진행회고성분석，기중45례환자접수료5-FU/LV화료방안，54례접수료FOLFOX4방안，비교2조환자림상료효급화료불량반응。결과 FOLFOX4조객관완해솔（ ORR ）위50.0％，현저고우5-FU/LV조（28.9％）（ P＜0.05）。5-FU/LV여FOLFOX4방안불량반응주요위립세포감소화위장도불량반응，2조환자Ⅲ～Ⅳ불량반응발생솔차이무통계학의의（ P＞0.05）。결론 FOLFOX4방안치료만기결직장암객관완해솔교고，차불량반응발생솔여5-FU/LV방안무명현차이。
Objective To evaluate the efficacy and safety of two adju-vant chemotherapy regimens of 5-FU/LV and FOLFOX4 in patients with advanced colorectal cancer.Methods Ninety-nine patients with ad-vanced colorectal cancer were analyzed retrospectively.Of the 99 includ-ed patients , 45 were given the regimen of 5 FU/LV chemotherapy and other 54 subjects were given FOLFOX4 chemotherapy regimen.The clini-cal efficacy and adverse drug reactions in two groups were recorded and compared.Results The objective response rate ( ORR ) of FOLFOX4 group ( 50.0%) was much higher than 5 -FU/LV group ( 28.9%).The main adverse drug reactions were granulopenia and gastrointestinal reactions in the two groups , but there was no significant statistical differ-ence ( P>0.05 ).Conclusion Compared with advanced 5 -FU/LV chemotherapy regimen , FOLFOX4 therapy is more effective for patients with colorectal cancer , with similar incidence of adverse drug reactions.