解放军医药杂志
解放軍醫藥雜誌
해방군의약잡지
MEDICAL&PHARMACEUTICAL JOURNAL OF CHINESE PEOPLE'S LIBERATION ARMY
2014年
8期
25-28
,共4页
彭永%吕肖锋%王亚双%程千鹏%赵晶%张星光%武晋晓%丁林%陈少敏
彭永%呂肖鋒%王亞雙%程韆鵬%趙晶%張星光%武晉曉%丁林%陳少敏
팽영%려초봉%왕아쌍%정천붕%조정%장성광%무진효%정림%진소민
糖尿病,2型%下肢血管病变%血糖波动%超敏C反应蛋白
糖尿病,2型%下肢血管病變%血糖波動%超敏C反應蛋白
당뇨병,2형%하지혈관병변%혈당파동%초민C반응단백
Diabetes mellitus,type 2%Lower extremity vascular lesion%Blood sugar fluctuations%High sensitiv-ity C reactive protein
目的：探讨2型糖尿病( T2DM)合并下肢血管病变( diabetic lower extremity arterial disease, DLEAD)患者血糖波动与超敏C反应蛋白( high sensitivity C reactive protein, hs-CRP)的相关性。方法选择2013年4月-2014年1月就诊于北京军区总医院内分泌科的T2DM 60例,分为单纯T2DM组(T2DM组)与合并DLEAD组(DLEAD组),每组30例。检测两组hs-CRP；应用动态血糖监测系统( monitored continuous glucose monitoring system, CGMS)行连续72 h血糖监测,比较两组日内平均血糖波动幅度( mean amplitude of glycemic excursions, MAGE)与全天血糖标准差( standard deviation of blood glucose, SDBG)；分析hs-CRP与血糖波动参数及临床生化指标的相关性。结果 DLEAD组MAGE、SDBG、hs-CRP比T2DM 组均明显升高(P <0.05)。 HbA1c、SDBG、MAGE 与 hs-CRP 呈显著正相关(r =0.494、0.333、0.57, P<0.05),SDBG、HbA1c与hs-CRP呈独立相关(Y=1.923+0.622HbA1c+0.961SDBG)。结论T2DM合并DLEAD患者的血糖波动与hs-CRP密切相关,可能通过诱发体内炎症反应引起DLEAD的发生、发展。
目的：探討2型糖尿病( T2DM)閤併下肢血管病變( diabetic lower extremity arterial disease, DLEAD)患者血糖波動與超敏C反應蛋白( high sensitivity C reactive protein, hs-CRP)的相關性。方法選擇2013年4月-2014年1月就診于北京軍區總醫院內分泌科的T2DM 60例,分為單純T2DM組(T2DM組)與閤併DLEAD組(DLEAD組),每組30例。檢測兩組hs-CRP；應用動態血糖鑑測繫統( monitored continuous glucose monitoring system, CGMS)行連續72 h血糖鑑測,比較兩組日內平均血糖波動幅度( mean amplitude of glycemic excursions, MAGE)與全天血糖標準差( standard deviation of blood glucose, SDBG)；分析hs-CRP與血糖波動參數及臨床生化指標的相關性。結果 DLEAD組MAGE、SDBG、hs-CRP比T2DM 組均明顯升高(P <0.05)。 HbA1c、SDBG、MAGE 與 hs-CRP 呈顯著正相關(r =0.494、0.333、0.57, P<0.05),SDBG、HbA1c與hs-CRP呈獨立相關(Y=1.923+0.622HbA1c+0.961SDBG)。結論T2DM閤併DLEAD患者的血糖波動與hs-CRP密切相關,可能通過誘髮體內炎癥反應引起DLEAD的髮生、髮展。
목적：탐토2형당뇨병( T2DM)합병하지혈관병변( diabetic lower extremity arterial disease, DLEAD)환자혈당파동여초민C반응단백( high sensitivity C reactive protein, hs-CRP)적상관성。방법선택2013년4월-2014년1월취진우북경군구총의원내분비과적T2DM 60례,분위단순T2DM조(T2DM조)여합병DLEAD조(DLEAD조),매조30례。검측량조hs-CRP；응용동태혈당감측계통( monitored continuous glucose monitoring system, CGMS)행련속72 h혈당감측,비교량조일내평균혈당파동폭도( mean amplitude of glycemic excursions, MAGE)여전천혈당표준차( standard deviation of blood glucose, SDBG)；분석hs-CRP여혈당파동삼수급림상생화지표적상관성。결과 DLEAD조MAGE、SDBG、hs-CRP비T2DM 조균명현승고(P <0.05)。 HbA1c、SDBG、MAGE 여 hs-CRP 정현저정상관(r =0.494、0.333、0.57, P<0.05),SDBG、HbA1c여hs-CRP정독립상관(Y=1.923+0.622HbA1c+0.961SDBG)。결론T2DM합병DLEAD환자적혈당파동여hs-CRP밀절상관,가능통과유발체내염증반응인기DLEAD적발생、발전。
Objective To investigate the relationship between the blood sugar fluctuations with high sensitivity C reactive protein (hs-CRP) in type 2 diabetes patients (T2DM) with deep lower extremity vascular diseases (DLEAD). Methods A total of 60 patients with T2DM during April 2013 and January 2014 in Department of Endocrinology were di-vided into patients with T2DM group (group A, n=30) and patients with T2DM complicated with lower extremity vascu-lar diseases group (group B, n=30). The levels of hs-CRP in the two groups were detected respectively; blood sugar monitoring was also performed by continuous glucose monitoring system ( CGMS) for 72 h in the two groups, and the val-ues of mean amplitude of glycemic excursions ( MAGE ) and standard deviation of blood glucose ( SDBG ) in the two groups were compared;the relationship between the clinical biochemical indexes and blood sugar parameters with hs-CRP level was analyzed. Results The levels of MAGE, SDBG and hs-CRP in group B were significantly higher than those in group A (P<0. 05). The levels of HbA1c, SDBG and MAGE was positively related to hs-CRP level ( r =0. 494, 0. 333, 0. 57, P<0. 05); the levels of SDBG and HbA1c was independently related to hs-CRP level ( Y=1. 923 +0. 622HbA1c+0. 961SDBG). Conclusion Blood sugar fluctuations is closely related to hs-CRP level in T2DM patients with DLEAD, and it may cause or aggravate diabetic lower extremity vascular disease by inducing inflammatory reaction in vivo.
