肝脏
肝髒
간장
CHINESE HEPATOLOGY
2014年
8期
601-603
,共3页
赫崇安%张建成%王洪阳%岑冬梅
赫崇安%張建成%王洪暘%岑鼕梅
혁숭안%장건성%왕홍양%잠동매
肝细胞癌%CT 灌注成像%甲胎蛋白%鉴别%诊断
肝細胞癌%CT 灌註成像%甲胎蛋白%鑒彆%診斷
간세포암%CT 관주성상%갑태단백%감별%진단
Hepatocellular carcinoma%CT perfusion imaging%Alpha fetoprotein%Discriminant%Diagnosis
目的探讨 CT 灌注成像在 AFP 阴性及增强 CT 表现不典型的肝细胞癌(HCC)诊断及鉴别诊断中的应用价值。方法从2011年9月至2013年9月收治的 HCC 患者中随机选择14例进行研究,均予以64层螺旋 CT 灌注成像扫描。结果HCC 组病灶的平均通过时间(MTT)为(8.6±4.8)s,血管表面通透性(PS)为(28.8±19)mL·100 mL-1·min-1,较之非病灶区的(14.5±8.1)s 和(59.1±26)mL·100 mL-1·min-1,均呈现出显著减少的情况;HCC组病灶的肝动脉灌注分数(HAF)为0.432±0.197,较之非病灶区的0.105±0.113,则呈现出显著增加的情况(均 P <0.05)。HCC 组病灶的肝血容量(HBV)(30±20)mL/100 mL 和肝血流量(HBF)(232±170)mL·100 mL-1·min-1较之非病灶区(25±16)mL/100 mL、(175±76)mL·100 mL-1·min-1差异均无统计学意义(均 P >0.05)。在 HBF方面,肝血管瘤组病灶与 HCC 组病灶之间存在显著差异。肝局灶性结节增生与非结节区的各灌注参数大小基本一致,但肝局灶性结节增生的 HAF 小于非结节区。HCC 组病灶灌注参数合患者血清 AFP 之间不存在明显的相关性,PS (r=-0.1022,P =0.7520);HAF(r=-0.3138,P =0.2964);MTT(r =0.0416,P =0.8926);HBV(r =-0.2170,P =0.4765);HBF(r=-0.2152,P =-0.4801)。结论CT 灌注成像在 AFP 阴性及增强 CT 表现不典型的 HCC 诊断及鉴别诊断中具有重要的应用价值。
目的探討 CT 灌註成像在 AFP 陰性及增彊 CT 錶現不典型的肝細胞癌(HCC)診斷及鑒彆診斷中的應用價值。方法從2011年9月至2013年9月收治的 HCC 患者中隨機選擇14例進行研究,均予以64層螺鏇 CT 灌註成像掃描。結果HCC 組病竈的平均通過時間(MTT)為(8.6±4.8)s,血管錶麵通透性(PS)為(28.8±19)mL·100 mL-1·min-1,較之非病竈區的(14.5±8.1)s 和(59.1±26)mL·100 mL-1·min-1,均呈現齣顯著減少的情況;HCC組病竈的肝動脈灌註分數(HAF)為0.432±0.197,較之非病竈區的0.105±0.113,則呈現齣顯著增加的情況(均 P <0.05)。HCC 組病竈的肝血容量(HBV)(30±20)mL/100 mL 和肝血流量(HBF)(232±170)mL·100 mL-1·min-1較之非病竈區(25±16)mL/100 mL、(175±76)mL·100 mL-1·min-1差異均無統計學意義(均 P >0.05)。在 HBF方麵,肝血管瘤組病竈與 HCC 組病竈之間存在顯著差異。肝跼竈性結節增生與非結節區的各灌註參數大小基本一緻,但肝跼竈性結節增生的 HAF 小于非結節區。HCC 組病竈灌註參數閤患者血清 AFP 之間不存在明顯的相關性,PS (r=-0.1022,P =0.7520);HAF(r=-0.3138,P =0.2964);MTT(r =0.0416,P =0.8926);HBV(r =-0.2170,P =0.4765);HBF(r=-0.2152,P =-0.4801)。結論CT 灌註成像在 AFP 陰性及增彊 CT 錶現不典型的 HCC 診斷及鑒彆診斷中具有重要的應用價值。
목적탐토 CT 관주성상재 AFP 음성급증강 CT 표현불전형적간세포암(HCC)진단급감별진단중적응용개치。방법종2011년9월지2013년9월수치적 HCC 환자중수궤선택14례진행연구,균여이64층라선 CT 관주성상소묘。결과HCC 조병조적평균통과시간(MTT)위(8.6±4.8)s,혈관표면통투성(PS)위(28.8±19)mL·100 mL-1·min-1,교지비병조구적(14.5±8.1)s 화(59.1±26)mL·100 mL-1·min-1,균정현출현저감소적정황;HCC조병조적간동맥관주분수(HAF)위0.432±0.197,교지비병조구적0.105±0.113,칙정현출현저증가적정황(균 P <0.05)。HCC 조병조적간혈용량(HBV)(30±20)mL/100 mL 화간혈류량(HBF)(232±170)mL·100 mL-1·min-1교지비병조구(25±16)mL/100 mL、(175±76)mL·100 mL-1·min-1차이균무통계학의의(균 P >0.05)。재 HBF방면,간혈관류조병조여 HCC 조병조지간존재현저차이。간국조성결절증생여비결절구적각관주삼수대소기본일치,단간국조성결절증생적 HAF 소우비결절구。HCC 조병조관주삼수합환자혈청 AFP 지간불존재명현적상관성,PS (r=-0.1022,P =0.7520);HAF(r=-0.3138,P =0.2964);MTT(r =0.0416,P =0.8926);HBV(r =-0.2170,P =0.4765);HBF(r=-0.2152,P =-0.4801)。결론CT 관주성상재 AFP 음성급증강 CT 표현불전형적 HCC 진단급감별진단중구유중요적응용개치。
Objective To explore the application of CT perfusion imaging in diagnosis and differential diagnosis of hepatocellular carcinoma (HCC)with negative AFP and/or atypical enhanced CT appearances.Methods Fourteen patients with hepatocellular carcinoma in our hospital from September 2011 to September 2013 were selected and underwent 64 slice spiral CT perfusion imaging.Results MTT of lesion areas in HCC group was 8.6±4.8s,PS was 28.8 ±19 mL·100 mL-1 ·min-1 ,while MTT and PS of the non-lesion areas were 14.5 ±8.1 s and 59.1 ±26 mL· 100mL-1 · min-1 ,respectively,the differences were statistically significant (all P < 0.05 ).The hepatic arterial perfusion fraction (HAF)of lesion areas in HCC group was 0.432 ±0.197,which was significant increased compared with non-lesion areas of 0.105±0.113 (P <0.05).There was no significant differences of HBV and HBF between lesion areas (30±20 mL/100 mL,232±170mL·100 mL-1 ·min-1 )and non-lesion areas (25±16 mL/100 mL,175±76 mL ·100 mL-1 ·min-1 )in HCC group,respectively (P >0.05 ).There was no obvious correlation between serum AFP and parameters of CT perfusion imaging in lesion areas,the results are as follows:PS (r=-0.1022,P =0.7520);HAF (r=-0.3138,P =0.2964);MTT(r=0.0416,P =0.8926);HBV (r = -0.2170,P =0.4765 );HBF (r = -0.2152, P =- 0.4801 ).Conclusion CT perfusion imaging has an important application value in diagnosis and differential diagnosis of HCC with negative AFP and/or atypical enhanced CT appearances.