CAJ | 학술논문

目的：探讨老年全髋关节置换术后认知功能障碍与围术期炎性反应之间的相关性。方法将全髋关节置换术治疗的60例老年患者分为认知功能障碍组（25例）和非认知功能障碍组（35例），测定围术期炎性因子。结果认知功能障碍组患者术后1 h、6 h的IL-1β、IL-6较术前有明显提高，术后6 h C反应蛋白（CRP）较术前有提高（P＜0．05）；非认知功能障碍组术后1 h、6 h的IL-6较术前有升高，术后6 h CRP较术前有提高（P＜0．05）；认知功能障碍组中术后1 h的IL-1β和术后6 h的IL-6均高于非认知功能障碍组（ P＜0．05）。结论老年全髋关节置换术后早期的认知功能障碍与围术期的炎性因子密切相关。
목적：탐토노년전관관절치환술후인지공능장애여위술기염성반응지간적상관성。방법장전관관절치환술치료적60례노년환자분위인지공능장애조（25례）화비인지공능장애조（35례），측정위술기염성인자。결과인지공능장애조환자술후1 h、6 h적IL-1β、IL-6교술전유명현제고，술후6 h C반응단백（CRP）교술전유제고（P＜0．05）；비인지공능장애조술후1 h、6 h적IL-6교술전유승고，술후6 h CRP교술전유제고（P＜0．05）；인지공능장애조중술후1 h적IL-1β화술후6 h적IL-6균고우비인지공능장애조（ P＜0．05）。결론노년전관관절치환술후조기적인지공능장애여위술기적염성인자밀절상관。
Objective To investigate the correlation between postoperative cognitive dysfunction and perioperative inflammatory re -sponse in elderly total hip replacement .Methods Sixty cases of elderly patients with total hip arthroplasty were divided into cognitive dys -function group (25 cases) and non-cognitive dysfunction group (35 cases),and the perioperative inflammatory cytokines were measured .Re-sults Postoperative 1 h and 6 h IL-1β,IL-6 were significantly improved in cognitive dysfunction group compared with those before surgery , and postoperative 6 h CRP was improved compared with that before surgery (P<0.05);postoperative 1 h and 6h IL-6 were increased in non-surgical cognitive dysfunction group compared with those before surgery ,and postoperative 6h CRP was improved compared with that before surgery(P<0.05);in cognitive dysfunction group ,postoperative 1 h IL-1βand postoperative 6h IL-6 were higher than those of the non-cogni-tive dysfunction group (P<0.05).Conclusion The postoperative cognitive dysfunction in elderly total hip arthroplasty is closely related to the perioperative inflammatory cytokines .