CAJ | 학술논문

目的：探讨脑梗死后认知功能障碍与血尿酸的关系。方法选择110例脑梗死患者，根据认知功能差异分为：A组（63例），存在认知功能障碍；B组（47例），认知功能正常。应用蒙特利尔认知评估量表（ MoCA）及简易智能精神状态量表（ MMSE）评估两组患者的认知功能并进行比较，同时检测两组血尿酸的水平并进行比较。应用多元Logistic回归分析，评估脑梗死患者认知功能相关的危险因素以及血清尿酸水平与各种认知功能障碍的关系。结果与B组相比，A组患者的认知功能评分（MSSE评分及MOCA评分）均显著较低，而血尿酸水平明显高（P＜0．05）。应用多元Logistic回归分析显示，女性及血清尿酸水平是脑梗死认知功能障碍的独立危险因素，且血尿酸水平是记忆和语言功能的独立危险因素。结论脑梗死后认知功能水平与血尿酸水平呈负相关，且高尿酸血症对脑梗死后认知障碍尤其是在短时记忆和语言上有明显影响。
목적：탐토뇌경사후인지공능장애여혈뇨산적관계。방법선택110례뇌경사환자，근거인지공능차이분위：A조（63례），존재인지공능장애；B조（47례），인지공능정상。응용몽특리이인지평고량표（ MoCA）급간역지능정신상태량표（ MMSE）평고량조환자적인지공능병진행비교，동시검측량조혈뇨산적수평병진행비교。응용다원Logistic회귀분석，평고뇌경사환자인지공능상관적위험인소이급혈청뇨산수평여각충인지공능장애적관계。결과여B조상비，A조환자적인지공능평분（MSSE평분급MOCA평분）균현저교저，이혈뇨산수평명현고（P＜0．05）。응용다원Logistic회귀분석현시，녀성급혈청뇨산수평시뇌경사인지공능장애적독립위험인소，차혈뇨산수평시기억화어언공능적독립위험인소。결론뇌경사후인지공능수평여혈뇨산수평정부상관，차고뇨산혈증대뇌경사후인지장애우기시재단시기억화어언상유명현영향。
Objective To investigate the relation between cognitive impairment and serum uric acid in patients with cerebral infarc -tion (CI).Methods A total of 110 patients with CI were chosen and divided into two groups ,namely Group A (63 cases,cognitive impair-ment) and Group B (47 cases,normal cognitive function),according to cognitive function variation .The cognitive functions were measured by Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE),and were compared between two groups.The serum level of uric acid was detected and compared between two groups .The risk factor of clinical factors to cognitive function in patients with CI was assessed by multivariate Logistic regression analysis .And the correlation of the serum level of uric acid and all kinds of cognitive impairment was also assessed by multivariate Logistic regression analysis .Results Compared to group B ,the scores of MoCA and MMSE in group A were lower (P<0.05),but the serum level of uric acid in group A was higher (P<0.05).The factors of female and the serum level of uric acid were risk factors for cognitive function in patients with CI by multivariate Logistic regression analysis .And the serum level of uric acid was the risk factor to short-term memory and verbal function .Conclusion Cognitive impairment and level of serum uric acid in patients with cere-bral infarction are negatively correlated .Hyperuricemia has marked influence on the short term memory and language for patients with CI .