CAJ | 학술논문

目的：观察五藤二草汤对活动期类风湿关节炎(RA)的临床疗效及其对白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的影响。方法将65例活动期RA患者随机分为对照组(32例)和治疗组(33例)。对照组口服甲氨蝶呤片10 mg,每周1次；硫酸羟氯喹片200 mg,每日2次；双氯芬酸钠缓释片75 mg,每日2次。治疗组在对照组的基础上加用五藤二草汤,每日3次,口服。疗程12周。于治疗后观察临床疗效和实验室指标变化及不良反应情况。结果治疗后2组关节疼痛数、关节肿胀数较治疗前显著好转(P＜0.05),治疗后关节疼痛数2组比较差异有统计学意义(P＜0.05)。治疗后患者评分、医生评估优于治疗前(P＜0.05),2组比较差异有统计学意义(P＜0.05)。治疗后红细胞沉降率、C反应蛋白、IL-6、TNF-α水平显著降低(P＜0.05),治疗组改善优于对照组(P＜0.05)。治疗组不良反应2例,对照组1例。结论五藤二草汤治疗活动期RA疗效显著,且能下调IL-6及TNF-α水平。
목적：관찰오등이초탕대활동기류풍습관절염(RA)적림상료효급기대백세포개소-6(IL-6)、종류배사인자-α(TNF-α)적영향。방법장65례활동기RA환자수궤분위대조조(32례)화치료조(33례)。대조조구복갑안접령편10 mg,매주1차；류산간록규편200 mg,매일2차；쌍록분산납완석편75 mg,매일2차。치료조재대조조적기출상가용오등이초탕,매일3차,구복。료정12주。우치료후관찰림상료효화실험실지표변화급불량반응정황。결과치료후2조관절동통수、관절종창수교치료전현저호전(P＜0.05),치료후관절동통수2조비교차이유통계학의의(P＜0.05)。치료후환자평분、의생평고우우치료전(P＜0.05),2조비교차이유통계학의의(P＜0.05)。치료후홍세포침강솔、C반응단백、IL-6、TNF-α수평현저강저(P＜0.05),치료조개선우우대조조(P＜0.05)。치료조불량반응2례,대조조1례。결론오등이초탕치료활동기RA료효현저,차능하조IL-6급TNF-α수평。
Objective To observe the efficacy of Wuteng Ercao decoction in treating active rheumatoid arthritis (RA) and its effects on the levels of cytokine interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α).Methods Sixty-five patients with active RA were randomly divided into treatment group (33 cases) and control group (32 cases). Patients in the control group were administered with methotrexate tablets 10 mg, oral taking, once a week;hydroxychloroquine sulfate tablets 200 mg, oral taking, twice a day;diclofenac sodium sustained release tablets 75 mg, oral taking, twice a day. Patients in the treatment group were administered with Wuteng Ercao decoction additionally, oral taking, three times a day. The treatment lasted for 12 weeks. The changes and untoward effects of various clinical and laboratory indicators were observed before and after treatment.Results After treatment, the tender joint count, swollen joint count, patient’s global assessment, and physician’s global assessment were improved (P<0.05), with statistical significance between the two groups (P<0.05). The levels of ESR, CRP, IL-6 and TNF-α decreased significantly after treatment (P<0.05), but those were more significantly in treatment group (P<0.05). There were 2 cases with untoward effects in the treatment group and 1 case in the control group (P>0.05).Conclusion Wuteng Ercao decoction is effective in patients with active RA and it can reduce the levels of IL-6 and TNF-α.