CAJ | 학술논문

目的：分析《中华人民共和国卫生部药品标准·中药成方制剂》(以下简称《中药部颁标准》)含生地黄方剂组方规律，为临床应用及新药研发提供参考。方法借助中医传承辅助平台(V2.0)软件，对《中药成方制剂》中含有生地黄方剂收集整理，构建数据库，采用关联规则、改进的互信息法等数据挖掘方法，分析其主治疾病、证候规律及常用配伍组合。结果含有生地黄方剂共357首，常用药物组合17个；主治疾病22种，对其中2种高频疾病“不寐”、“眩晕”常用药组合对比分析，显示生地黄不同配伍治疗作用不同。结论《中药部颁标准》中含生地黄方剂所用药物多具有清热凉血、养阴生津功效，用药较为集中，组方法度清晰；用药规律反映了生地黄治疗不同疾病时的配伍特点，为充分发挥生地黄的功效及临证科学组方提供依据。
목적：분석《중화인민공화국위생부약품표준·중약성방제제》(이하간칭《중약부반표준》)함생지황방제조방규률，위림상응용급신약연발제공삼고。방법차조중의전승보조평태(V2.0)연건，대《중약성방제제》중함유생지황방제수집정리，구건수거고，채용관련규칙、개진적호신식법등수거알굴방법，분석기주치질병、증후규률급상용배오조합。결과함유생지황방제공357수，상용약물조합17개；주치질병22충，대기중2충고빈질병“불매”、“현훈”상용약조합대비분석，현시생지황불동배오치료작용불동。결론《중약부반표준》중함생지황방제소용약물다구유청열량혈、양음생진공효，용약교위집중，조방법도청석；용약규률반영료생지황치료불동질병시적배오특점，위충분발휘생지황적공효급림증과학조방제공의거。
Objective To analyze the composition principles of Chinese patent drugs containing Rehmanniae Radix;To provide reference for clinical application and new drug research and development.Methods Based on the software Traditional Chinese Medicine Inheritance Support System (V2.0), the authors built prescription database containing Rehmanniae Radix in National Standard for Chinese Patent Drugs (NSCPD). Then the authors adopted the statistical module by using data mining methods such as association rules and improved mutual information method, with a purpose to analyze the attending disease, combination rules and the core groups in prescriptions containing Rehmanniae Radix.Results In 357 prescriptions containing Rehmanniae Radix, 17 most commonly used drug combinations were mined. Meanwhile, two diseases, namely, insomnia and vertigo were chosen from the 22 diseases that Rehmanniae Radix was most frequently used to make deeper analysis, showing that Rehmanniae Radix can achieve different therapeutic effects through different compatibility.Conclusion Prescriptions containing Rehmanniae Radixin NSCPD mainly concentrate on clear heat and cool blood, and nourish Yin. The composition principles obtained from the research that Rehmanniae Radix used when curing different diseases can fully play the efficacy of RehmanniaeRadix and provide evidence for clinical scientific formulae.