CAJ | 학술논문

本文综述了自1972年青蒿素问世以来，研究者们在青蒿素类抗疟药的作用机理方面所做的研究工作，包括采用电子显微镜技术的超微结构病理学研究、采用生化药理学方法研究青蒿素对疟原虫代谢和疟色素凝集的影响，并对氧化损伤及铁离子作用机理的国内外研究情况进行了梗概的讨论。
본문종술료자1972년청호소문세이래，연구자문재청호소류항학약적작용궤리방면소주적연구공작，포괄채용전자현미경기술적초미결구병이학연구、채용생화약이학방법연구청호소대학원충대사화학색소응집적영향，병대양화손상급철리자작용궤리적국내외연구정황진행료경개적토론。
Studies on mechanisms of antimalarial action of artemisinin and its derivatives had been reviewed after artemisinin as an antimalarial drug was developed in 1972. The research work, which was mainly done by Chinese scholars, was introduced in the paper, and comprised 4 aspects:histopathology on the ultrastructure by electro-microscopy, the metabolism including the pigment clumping of the malarial parasite by biochemical pharmacology, and oxidation and Fe iron’s effect that were discussed in details based on studies from both domestic and international labs.