药品评价
藥品評價
약품평개
DRUG REEVALUATION
2014年
12期
28-31
,共4页
高哲%赵青威%杨志海%胡燕%张相宜
高哲%趙青威%楊誌海%鬍燕%張相宜
고철%조청위%양지해%호연%장상의
全肠外营养液%pH值%电解质%稳定性
全腸外營養液%pH值%電解質%穩定性
전장외영양액%pH치%전해질%은정성
Total Parenteral Nutrition%pH%Electrolyte%Stablility
目的：考察我院一份全肠外营养液处方在不同配制顺序下溶液pH值变化，以及一价电解质浓度对该TPN液稳定性的影响，为今后同类TPN的稳定性提供参考。方法：6组全肠外营养液分别加入不同复方氨基酸注射液和不同浓度一价电解质(Na+浓度)，于各步骤混合后0h及20℃~22℃下贮存12、24h后分别取样测定pH值，并肉眼观察其外观变化。结果：不同配制顺序下该全肠外营养液的pH值在24h内稳定，同样处方比例下加入复方氨基酸注射液(18AA-III)的出现分层现象，加入复方氨基酸注射液(18AA-II)的未发生明显变化；加入Na+终浓度100、150、200、250mmol/L的TPN液24h后均未出现分层析出现象。结论：该份全肠外营养液处方在不同配制顺序下溶液pH值无变化，一价电解质250mmol/L对该处方的24h稳定性无影响，不同复方氨基酸注射液的选择对全肠外营养液稳定性有影响。
目的：攷察我院一份全腸外營養液處方在不同配製順序下溶液pH值變化，以及一價電解質濃度對該TPN液穩定性的影響，為今後同類TPN的穩定性提供參攷。方法：6組全腸外營養液分彆加入不同複方氨基痠註射液和不同濃度一價電解質(Na+濃度)，于各步驟混閤後0h及20℃~22℃下貯存12、24h後分彆取樣測定pH值，併肉眼觀察其外觀變化。結果：不同配製順序下該全腸外營養液的pH值在24h內穩定，同樣處方比例下加入複方氨基痠註射液(18AA-III)的齣現分層現象，加入複方氨基痠註射液(18AA-II)的未髮生明顯變化；加入Na+終濃度100、150、200、250mmol/L的TPN液24h後均未齣現分層析齣現象。結論：該份全腸外營養液處方在不同配製順序下溶液pH值無變化，一價電解質250mmol/L對該處方的24h穩定性無影響，不同複方氨基痠註射液的選擇對全腸外營養液穩定性有影響。
목적：고찰아원일빈전장외영양액처방재불동배제순서하용액pH치변화，이급일개전해질농도대해TPN액은정성적영향，위금후동류TPN적은정성제공삼고。방법：6조전장외영양액분별가입불동복방안기산주사액화불동농도일개전해질(Na+농도)，우각보취혼합후0h급20℃~22℃하저존12、24h후분별취양측정pH치，병육안관찰기외관변화。결과：불동배제순서하해전장외영양액적pH치재24h내은정，동양처방비례하가입복방안기산주사액(18AA-III)적출현분층현상，가입복방안기산주사액(18AA-II)적미발생명현변화；가입Na+종농도100、150、200、250mmol/L적TPN액24h후균미출현분층석출현상。결론：해빈전장외영양액처방재불동배제순서하용액pH치무변화，일개전해질250mmol/L대해처방적24h은정성무영향，불동복방안기산주사액적선택대전장외영양액은정성유영향。
Objective:To investigate the pH value and monovalent electrolyte concentration in different preparation order and its impact on the stability of a total parenteral nutrient formulation and to provide a reference for the future stability of similar TPN preparation. Method:6 groups of total parenteral nutrients were injected by different compound amino acid injections and different concentrations of monovalent electrolyte concentration (Na+). 0 h, 12 h, 24h after each mixing step under 20℃~22℃storage, samplings were drawed to determine the pH value, and the changes in appearance were observed. Results:The pH value under different preparation order was stable within 24 h. Stratified phenomenon appeared when compound amino acid injection (18AA-III) was added to the nutrient solution while the solution did not change significantly when compound amino acid injection (18AA-II) was added under the same prescription proportion;TPN with Na+concentration at 100, 150, 200 and 250 mmol/L showed no stratified phenomenon 24h after preparation. Conclusion: pH value of the TPN under different preparation order was stable. Monovalent electrolyte up to 250 mmol/L had no effect on 24h stability of this prescription. Different compound amino acid injection had effects on the stability of total parenteral nutrition solution.
