药品评价
藥品評價
약품평개
DRUG REEVALUATION
2014年
12期
18-20,31
,共4页
陈兆群%蔡蔚斌%陈怀%陈展祥%方少虹
陳兆群%蔡蔚斌%陳懷%陳展祥%方少虹
진조군%채위빈%진부%진전상%방소홍
香连丸%肠黏膜屏障%梗阻性黄疸%二胺氧化酶
香連汍%腸黏膜屏障%梗阻性黃疸%二胺氧化酶
향련환%장점막병장%경조성황달%이알양화매
Xianglian Pill%Intestinal Mucosal Barrier%Obstructive Jaundice%Diamine Oxidase
目的：研究香连丸有效部位对梗阻性黄疸引起的肠黏膜受损的治疗作用。方法：建立梗阻性黄疸引起的肠黏膜受损的家兔模型，观察各组家兔小肠组织病理学变化、血清胆红素和直接胆红素、血二胺氧化酶(DAO)、血清内毒素(ET)的含量。结果：香连丸有效部位能显著减轻家兔小肠黏膜组织病理学损伤，降低血中二胺氧化酶及血清内毒素的水平。结论：香连丸有效部位对家兔肠黏膜屏障有保护作用。
目的：研究香連汍有效部位對梗阻性黃疸引起的腸黏膜受損的治療作用。方法：建立梗阻性黃疸引起的腸黏膜受損的傢兔模型，觀察各組傢兔小腸組織病理學變化、血清膽紅素和直接膽紅素、血二胺氧化酶(DAO)、血清內毒素(ET)的含量。結果：香連汍有效部位能顯著減輕傢兔小腸黏膜組織病理學損傷，降低血中二胺氧化酶及血清內毒素的水平。結論：香連汍有效部位對傢兔腸黏膜屏障有保護作用。
목적：연구향련환유효부위대경조성황달인기적장점막수손적치료작용。방법：건립경조성황달인기적장점막수손적가토모형，관찰각조가토소장조직병이학변화、혈청담홍소화직접담홍소、혈이알양화매(DAO)、혈청내독소(ET)적함량。결과：향련환유효부위능현저감경가토소장점막조직병이학손상，강저혈중이알양화매급혈청내독소적수평。결론：향련환유효부위대가토장점막병장유보호작용。
Objectives: To investigate the therapeutic effects of Xianglian Pill's effective fraction on damaged intestinal mucosal barrier in Rabbit with obstructive jaundice. Methods:The model of rabbit obstructive jaundice was built by ligaturing common bile duct for three days. The histopathological changes of mucous membrane lining the small intestine were observed and the content of hemobilirubin, diamine oxidase(DAO)、endotoxin(ET) were detected. Results: The effective fraction of Xianglian pill could significantly reduce the histopathological injury of rabbit small intestinal mucosal and reduce the levels of DAO and ET. Conclusion:Effective fraction of Xianglian Pill had a protective effect on rabbit intestinal mucosal barrier.
