CAJ | 학술논문

目的：探讨血清神经元特异性烯醇化酶（ NSE）水平在对慢性阻塞性肺疾病急性加重期（ AECOPD）并肺性脑病患者脑功能异常评价中的作用。方法选择驻马店市中心医院137例慢性阻塞性肺疾病（ COPD）患者，其中AECOPD患者（ A组）36例，COPD稳定期患者101例（ B组），同时选择我院健康体检者50例为对照组（ C组），分别对三组受检者采取NSE水平检测及脑电图检查，并对3组受检者的NSE检测水平及脑电图检查结果进行比较分析。同时，将137例COPD患者根据NSE正常水平（≤15μg/L）为界限，分为≤15μg/L组及﹥15μg/L组，并对两组脑电图异常率进行比较。结果 A 组的血清 NSE 水平及脑电图异常率显著高于 B、C 两组（ P ﹤0.05），B、C两组受检者的血清NSE水平比较差异无统计学意义（P﹥0.05）。NSE≤15μg/L组患者的脑电图异常率显著低于NSE﹥15μg/L组（χ2=94.97，P﹤0.01）。结论 AECOPD患者的血清NSE水平显著高于COPD稳定期患者及正常人群，且血清NSE水平与脑电图异常情况存在对应关系，并可用于评估AECOPD并肺性脑病患者的脑功能异常情况。
목적：탐토혈청신경원특이성희순화매（ NSE）수평재대만성조새성폐질병급성가중기（ AECOPD）병폐성뇌병환자뇌공능이상평개중적작용。방법선택주마점시중심의원137례만성조새성폐질병（ COPD）환자，기중AECOPD환자（ A조）36례，COPD은정기환자101례（ B조），동시선택아원건강체검자50례위대조조（ C조），분별대삼조수검자채취NSE수평검측급뇌전도검사，병대3조수검자적NSE검측수평급뇌전도검사결과진행비교분석。동시，장137례COPD환자근거NSE정상수평（≤15μg/L）위계한，분위≤15μg/L조급﹥15μg/L조，병대량조뇌전도이상솔진행비교。결과 A 조적혈청 NSE 수평급뇌전도이상솔현저고우 B、C 량조（ P ﹤0.05），B、C량조수검자적혈청NSE수평비교차이무통계학의의（P﹥0.05）。NSE≤15μg/L조환자적뇌전도이상솔현저저우NSE﹥15μg/L조（χ2=94.97，P﹤0.01）。결론 AECOPD환자적혈청NSE수평현저고우COPD은정기환자급정상인군，차혈청NSE수평여뇌전도이상정황존재대응관계，병가용우평고AECOPD병폐성뇌병환자적뇌공능이상정황。
Objective To investigate the application value of serum neuron specific enolase ( NSE)levels detection on evaluating the brain function abnormality in patients with acute exacerbation of chronic obstructive pulmonary disease( AECOPD)combined with pulmonary encephalopathy. Methods One hundred and thirty-seven patients with COPD were divided into AECOPD group( group A,36 cases) and COPD group(group B,101 cases),50 healthy people were chose in control group(group C). All the cases in the three groups received NSE level detection and electrocardiogram( EEG)examination, NSE level and electrocardiogram of the three groups were analyzed. One hundred and thirty-seven pa-tients with COPD were divided into≤15μg/L group and ﹥15 μg/L group according to NSE normal lev-el(≤15 μg/L),the abnormal rates of EEG of the two groups were compared. Results The abnormal rate of EEG and serum NSE level of group A was higher than that of group B and C significantly( P﹤0. 05 ),serum NSE level was not different between group B and C( P﹥0. 05 ). The abnormal rate of EEG in NSE≤15 μg/L group was lower than that in NSE ﹥15 μg/L group significantly(χ2 =94. 97 ,P ﹤0. 01). Conclusions Serum NSE level of AECOPD patients is higher than that of COPD patients and healthy people,the level is related to the abnormal rate of EEG,and can be used to evaluate the brain function abnormality in patients with AECOPD combined with pulmonary encephalopathy.