中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2014年
16期
30-32
,共3页
丁娟%娄小平%高姗%付艳君
丁娟%婁小平%高姍%付豔君
정연%루소평%고산%부염군
妊娠期高血压疾病%血红素氧合酶-1%一氧化碳
妊娠期高血壓疾病%血紅素氧閤酶-1%一氧化碳
임신기고혈압질병%혈홍소양합매-1%일양화탄
Hypertensive disorder complicating pregnancy%Heme oxygenase-1%Carbon monoxide
目的：测定血红素氧合酶-1（HO-1）和内源性一氧化碳（CO）在妊娠期高血压疾病患者的胎盘和血清中的浓度，了解其表达和作用机制。方法选取2013年1月至2013年11月郑州大学第一附属医院产科妊娠期高血压疾病住院患者60例作为观察组，随机选取同时期60例正常足月妊娠孕妇作为对照组，两组均为剖宫产。测定两组胎盘和血浆中HO-1活性和内源性CO的水平。结果妊娠期高血压疾病患者胎盘和血浆中HO-1活性与CO含量均较正常孕妇明显降低（ P﹤0.01），不同程度妊娠期高血压疾病胎盘和血浆中HO-1活性与CO含量比较差异有统计学意义（ P﹤0.01），子痫患者的含量最低。同时妊娠期高血压疾病患者胎盘中HO-1活性与CO含量明显高于血浆中含量，HO-1活性与CO浓度呈显著正相关（P﹤0.01）。结论血清和胎盘溶浆中HO-1活性变化和CO浓度与子痫前期的病情发展有关，随着病情的加重而降低，可作为病情发展变化的观察指标之一，有一定的临床参考价值。
目的：測定血紅素氧閤酶-1（HO-1）和內源性一氧化碳（CO）在妊娠期高血壓疾病患者的胎盤和血清中的濃度，瞭解其錶達和作用機製。方法選取2013年1月至2013年11月鄭州大學第一附屬醫院產科妊娠期高血壓疾病住院患者60例作為觀察組，隨機選取同時期60例正常足月妊娠孕婦作為對照組，兩組均為剖宮產。測定兩組胎盤和血漿中HO-1活性和內源性CO的水平。結果妊娠期高血壓疾病患者胎盤和血漿中HO-1活性與CO含量均較正常孕婦明顯降低（ P﹤0.01），不同程度妊娠期高血壓疾病胎盤和血漿中HO-1活性與CO含量比較差異有統計學意義（ P﹤0.01），子癇患者的含量最低。同時妊娠期高血壓疾病患者胎盤中HO-1活性與CO含量明顯高于血漿中含量，HO-1活性與CO濃度呈顯著正相關（P﹤0.01）。結論血清和胎盤溶漿中HO-1活性變化和CO濃度與子癇前期的病情髮展有關，隨著病情的加重而降低，可作為病情髮展變化的觀察指標之一，有一定的臨床參攷價值。
목적：측정혈홍소양합매-1（HO-1）화내원성일양화탄（CO）재임신기고혈압질병환자적태반화혈청중적농도，료해기표체화작용궤제。방법선취2013년1월지2013년11월정주대학제일부속의원산과임신기고혈압질병주원환자60례작위관찰조，수궤선취동시기60례정상족월임신잉부작위대조조，량조균위부궁산。측정량조태반화혈장중HO-1활성화내원성CO적수평。결과임신기고혈압질병환자태반화혈장중HO-1활성여CO함량균교정상잉부명현강저（ P﹤0.01），불동정도임신기고혈압질병태반화혈장중HO-1활성여CO함량비교차이유통계학의의（ P﹤0.01），자간환자적함량최저。동시임신기고혈압질병환자태반중HO-1활성여CO함량명현고우혈장중함량，HO-1활성여CO농도정현저정상관（P﹤0.01）。결론혈청화태반용장중HO-1활성변화화CO농도여자간전기적병정발전유관，수착병정적가중이강저，가작위병정발전변화적관찰지표지일，유일정적림상삼고개치。
Objective To detect the serum and placenta levels of heme oxygenase-1( HO-1 )and endogenic carbon-monoxide( CO)in patients with gestational hypertension disease,and to investigate its expression and potential pathogenetic. Methods Sixty patients with pregnancy-induced hypertension disease( observation group)and sixty cases of normal pregnant women( control group)were selected,and both were cesarean delivery. Samples were taken from a top three hospital obstetrics from January 2013 to November 2013 . The HO-1 activity and endogenic CO levels in serum and placenta were detected in nor-mal pregnant women( n =60 ) and patients with pregnancy-induced hypertension disease( n =60 ) by Chalmers’s Dithionate. Results The HO-1activity and endogenic CO levels in serum and placenta of patients with pregnancy- induced hypertension disease were lower than those in normal pregnant women ( P﹤0. 01 ). The differences in the HO-1 activity and endogenic CO levels among different degree PIH patients were significant(P﹤0. 01),the levels in patients with eclampsia was lowest. Meanwhile,the HO-1 activity and endogenic CO levels in placenta were higher than those in serum of PIH patients, and there were positive correlation of HO-1 activity with endogenic CO levels in serum and placenta ( P﹤0. 01 ). Conclusions HO-1 activity and CO concentration in serum and placenta dissolving pulp is correlated with the progress of preeclampsia. With the condition aggravates,the levels de-crease. It can be regarded as one of the observation indicators in the development of illness and has certain clinical reference value.
