CAJ | 학술논문

目的：评价自制制剂与原研药的溶出行为相似性。方法基于药典中的溶出度测定方法，分别考察自制制剂与原研药品在纯水，0．1、0．05 mol/L 盐酸，pH4．5、pH6．8的介质，以及在25、50、75 r/min 转速时的溶出行为，并用 f2因子法比较溶出曲线。结果当转速为50 r/min 在5种介质中，f2因子分别为57．65，79．17，73．56，66．83和62．33；介质为0．1 mol/L 的盐酸，转速为25 r/min 和75 r/min 时，f2值分别为65．35、78．48。结论自制制剂与原研药各条件下的溶出曲线相似。
목적：평개자제제제여원연약적용출행위상사성。방법기우약전중적용출도측정방법，분별고찰자제제제여원연약품재순수，0．1、0．05 mol/L 염산，pH4．5、pH6．8적개질，이급재25、50、75 r/min 전속시적용출행위，병용 f2인자법비교용출곡선。결과당전속위50 r/min 재5충개질중，f2인자분별위57．65，79．17，73．56，66．83화62．33；개질위0．1 mol/L 적염산，전속위25 r/min 화75 r/min 시，f2치분별위65．35、78．48。결론자제제제여원연약각조건하적용출곡선상사。
Objective To evaluate the similarity of dissolution profiles of self-produced and original drug cefuroxime axetil tab-lets.Methods Based on the dissolution detection method in the Chinese Pharmacopoeia,the dissolution behaviors of the self-pro-duced preparation and original drug were investigated in pure water,0.1 mol/L hydrochloric acid,0.05 mol/L hydrochloric acid, pH4.5 and pH6.8 medium and the rotation speed of 50,25,75 r/mim.The stripping curves were evaluated by the f2 factor method. Results In the rotation speed of 50 r/min,the f2 factors in different mediums were 57.65,79.17,73.56,66.83 and 62.33 respec-tively;the medium was 0.1 mol/L hydrochloric acid with the rotation speed of 25,75 r/min,the f2 factors were 65.35 and 78.48 re-spectively.Conclusion The stripping curves of self-produced preparation and original drug are similar under various conditions.