CAJ | 학술논문

目的：青霉素 Etest 法评价肺炎链球菌苯唑西林的纸片筛选试验。方法对临床分离的96株肺炎链球菌非脑膜炎株，用 Etest 作为测定青霉素敏感性的标准方法，评价苯唑西林的纸片筛选试验的灵敏度和特异性。结果96株肺炎链球菌非脑膜炎株，用 Etest 测定青霉素敏感株（PSSP）为96．9％（93/96），青霉素中度敏感株（PISP）为3．1％（3/96），未发现青霉素耐药株（PRSP）。苯唑西林纸片法初筛出16株 PSSP，灵敏度为17．2％，特异性为100．0％。苯唑西林纸片法与 Etest 方法比较，差异有统计学意义（χ2＝77，P ＜0．01）。结论苯唑西林纸片法作为肺炎链球菌非脑膜炎株青霉素注射剂敏感性的初筛方法灵敏度低，大部分肺炎链球菌必须用 Etest 等 MIC 方法检测。
목적：청매소 Etest 법평개폐염련구균분서서림적지편사선시험。방법대림상분리적96주폐염련구균비뇌막염주，용 Etest 작위측정청매소민감성적표준방법，평개분서서림적지편사선시험적령민도화특이성。결과96주폐염련구균비뇌막염주，용 Etest 측정청매소민감주（PSSP）위96．9％（93/96），청매소중도민감주（PISP）위3．1％（3/96），미발현청매소내약주（PRSP）。분서서림지편법초사출16주 PSSP，령민도위17．2％，특이성위100．0％。분서서림지편법여 Etest 방법비교，차이유통계학의의（χ2＝77，P ＜0．01）。결론분서서림지편법작위폐염련구균비뇌막염주청매소주사제민감성적초사방법령민도저，대부분폐염련구균필수용 Etest 등 MIC 방법검측。
Objective To evaluate the oxacillin disk screening test for screening Streptococcus pneumoniae by the penicillin Etest method.Methods 96 clinically isolated non-meningitis strains of Streptococcus pneumoniae were collected.The sensitivity and spe-cificity of the oxacillin disc screening test was evaluated by the penicillin Etest method as a standard method for detecting the peni-cillin susceptibility.Results Among 96 non-meningitis strains of Streptococcus pneumoniae,the penicillin-susceptible Streptococcus pneumoniae(PSSP)strains detected by the penicillin Etest method accounted for 96.9%(93/96),the penicillin intermediate Strep-tococcus pneumoniae(PISP)strains accounted for 3.1%(3/96)and no penicillin resistant Streptococcus pneumoniae(PRSP)strain was found.But 16 PSSP strains were detected by the oxacillin disc screening test with the sensitivity of 17.2% and the specificity of 100.0%,respectively.The difference between the oxacillin disc screening test and the penicillin Etest method was statistically sig-nificant(χ2 =77,P <0.01 ).Conclusion The oxacillin disc screening test has the low sensitivity for preliminarily screening non-meningitis strains of Streptococcus pneumoniae.Most of Streptococcus pneumoniae must be detected by the minimum inhibitory concentration(MIC)methods such as the penicillin Etest method.