CAJ | 학술논문

目的：探讨血清抗环瓜氨酸肽抗体（抗-CCP）、碱性磷酸酶（ALP）、葡萄糖-6-磷酸异构酶（G6PI）和类风湿因子（RF）的检测在类风湿关节炎（RA）诊断中的意义。方法检测206例 RA 患者、68例其他自身免疫性疾病患者和48例健康体检者血清中 RF、抗-CCP、ALP 和 G6PI 的水平，同时测定红细胞沉降率（ESR）；计算每个指标的敏感性和特异性并分析与 RA 诊断的关系。结果 RA 组的各项血清指标水平明显高于其他两组（P ＜0．05），RF、抗-CCP 和 G6PI 对 RA 的敏感性相近；特异性方面抗-CCP 最高（94．8％），RF 和 G6PI 相近；而敏感性和特异性相对较低的 ALP 在一定程度上也反映了 RA 的潜在性。结论同时检测 RF、抗-CCP、G6PI 和 ALP 可以提高 RA 早期诊断的准确性，减少漏诊，指导临床治疗。
목적：탐토혈청항배과안산태항체（항-CCP）、감성린산매（ALP）、포도당-6-린산이구매（G6PI）화류풍습인자（RF）적검측재류풍습관절염（RA）진단중적의의。방법검측206례 RA 환자、68례기타자신면역성질병환자화48례건강체검자혈청중 RF、항-CCP、ALP 화 G6PI 적수평，동시측정홍세포침강솔（ESR）；계산매개지표적민감성화특이성병분석여 RA 진단적관계。결과 RA 조적각항혈청지표수평명현고우기타량조（P ＜0．05），RF、항-CCP 화 G6PI 대 RA 적민감성상근；특이성방면항-CCP 최고（94．8％），RF 화 G6PI 상근；이민감성화특이성상대교저적 ALP 재일정정도상야반영료 RA 적잠재성。결론동시검측 RF、항-CCP、G6PI 화 ALP 가이제고 RA 조기진단적준학성，감소루진，지도림상치료。
Objective To investigate the detection of anti-cyclic citrullinated peptide(anti-CCP)antibody,alkaline phosphatase (ALP),glucose-6-phosphate isomerase(G6PI)and rheumatoid factor(RF)in the diagnosis of rheumatoid arthritis(RA).Methods Serum RF,anti-CCP body,ALP and G6PI were detected in 206 cases of RA,68 cases of other autoimmune diseases and 48 persons with the healthy physical examination,at the same time the erythrocyte sedimentation rate(ESR)was measured;the sensitivity and specificity of each indicator and the relationship between each index and RA′s diagnosis.Results The serum level of each index in the RA group was significantly higher than that in the other two groups(P <0.05).The sensitivity of RF,anti-CCP antibody and G6PI for diagnosing RA is similar;the specificity of anti-CCP body was highest(94.8%),RF was similar to G6PI;ALP with rela-tively lower sensitivity and specificity also reflected the potential of RA to some extent.Conclusion The simultaneous detection of serum RF,anti-CCP body,G6PI and ALP can improve the accuracy of early diagnosis of RA,reduce the missed diagnosis and guide the clinical treatment.