国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2014年
16期
2183-2184
,共2页
血管生成素样蛋白%糖尿病,2 型%血管并发症
血管生成素樣蛋白%糖尿病,2 型%血管併髮癥
혈관생성소양단백%당뇨병,2 형%혈관병발증
angiopoietin like protein%diabetes mellitus,type 2%vascular complications
目的：探讨血管生成素样蛋白（Ang）1和 Ang-2水平在2型糖尿病（T2DM）患者中的表达以及与血管病变的关系。方法选取 T2DM 患者120例，其中并发大血管病变32例，微血管病变52例，无血管病变36例，同期选择健康体检者50例为对照组，分别检测研究对象中 Ang-1和 Ang-2、空腹血糖（FBG）和胰岛素（FINS）、糖化血红蛋白（HbA1c）水平并与对照组作比较。结果 T2DM 组中 Ang-1水平和对照组间比较差异无统计学意义（P ＞0．05）；Ang-2水平显著高于对照组（t ＝2．6，P ＜0．01）。T2DM 并发血管病变 Ang-2水平显著高于无血管病变组且与病变血管数量有关。Ang-2与胰岛素抵抗（HOMA-IR）、HbA1c 呈显著正相关（r 分别为0．577和0．509，P ＜0．01）；Ang-1和 HOMA-IR 则无相关性（P ＞0．05）。结论 T2DM 患者中 Ang-2水平显著升高，与 HbA1c 和胰岛素抵抗密切相关，并且 Ang-2可能参与了 T2DM 血管病变的发生和发展。
目的：探討血管生成素樣蛋白（Ang）1和 Ang-2水平在2型糖尿病（T2DM）患者中的錶達以及與血管病變的關繫。方法選取 T2DM 患者120例，其中併髮大血管病變32例，微血管病變52例，無血管病變36例，同期選擇健康體檢者50例為對照組，分彆檢測研究對象中 Ang-1和 Ang-2、空腹血糖（FBG）和胰島素（FINS）、糖化血紅蛋白（HbA1c）水平併與對照組作比較。結果 T2DM 組中 Ang-1水平和對照組間比較差異無統計學意義（P ＞0．05）；Ang-2水平顯著高于對照組（t ＝2．6，P ＜0．01）。T2DM 併髮血管病變 Ang-2水平顯著高于無血管病變組且與病變血管數量有關。Ang-2與胰島素牴抗（HOMA-IR）、HbA1c 呈顯著正相關（r 分彆為0．577和0．509，P ＜0．01）；Ang-1和 HOMA-IR 則無相關性（P ＞0．05）。結論 T2DM 患者中 Ang-2水平顯著升高，與 HbA1c 和胰島素牴抗密切相關，併且 Ang-2可能參與瞭 T2DM 血管病變的髮生和髮展。
목적：탐토혈관생성소양단백（Ang）1화 Ang-2수평재2형당뇨병（T2DM）환자중적표체이급여혈관병변적관계。방법선취 T2DM 환자120례，기중병발대혈관병변32례，미혈관병변52례，무혈관병변36례，동기선택건강체검자50례위대조조，분별검측연구대상중 Ang-1화 Ang-2、공복혈당（FBG）화이도소（FINS）、당화혈홍단백（HbA1c）수평병여대조조작비교。결과 T2DM 조중 Ang-1수평화대조조간비교차이무통계학의의（P ＞0．05）；Ang-2수평현저고우대조조（t ＝2．6，P ＜0．01）。T2DM 병발혈관병변 Ang-2수평현저고우무혈관병변조차여병변혈관수량유관。Ang-2여이도소저항（HOMA-IR）、HbA1c 정현저정상관（r 분별위0．577화0．509，P ＜0．01）；Ang-1화 HOMA-IR 칙무상관성（P ＞0．05）。결론 T2DM 환자중 Ang-2수평현저승고，여 HbA1c 화이도소저항밀절상관，병차 Ang-2가능삼여료 T2DM 혈관병변적발생화발전。
Objective To explore the expression of angiopoietin like protein-1(Ang-1)and angiopoietin like protein-2(Ang-2)in type 2 diabetes mellitus(T2DM)and its relationship with angiopathy.Methods Ang-1,Ang-2,FBG,FINS and HbA1c were meas-ured in 120 cases of T2DM,including 32 cases of macroangiopathy,52 cases of microangiopathy and 36 cases without angiopathy, and 50 healthy subjects with physical examination were selected as the control group.The detection results were compared between the two groups.Results Compared with control group,the Ang-1 level in the T2DM group was no statistical difference(P >0.05), but the Ang-2 level was significantly higher than that in the control group(t=2.6,P <0.01).The Ang-2 level in T2DM with com-plicating angiopathy was significantly higher than that in T2DM without angiopathy and closely correlated with the blood vessel number of angiopathy.The Ang-2 level in T2DM was significantly positively correlated with HOMA-IR and HbA1c(r=0.577 and 0.509,P <0.01),and there was no correlation between the Ang-1 level and HOMA-IR(P >0.05).Conclusion The Ang-2 level in the patients with T2DM is significantly increased,which is closely related with HbA1c and insulin resistance,furthermore Ang-2 may participate in the generation and development of pathogenesis in T2DM.
