CAJ | 학술논문

目的：探讨血清缺血修饰清蛋白（IMA）在急性冠状动脉综合征（ACS）早期诊断中的价值。方法检测117例 ACS患者及100例健康体检者血清中 IMA 及肌酸激酶同工酶（CK-MB）水平，分析 IMA 检测对于 ACS 早期诊断中的价值。结果当临界值为73．25 U/mL 时，血清 IMA 检测判断 ACS 的灵敏度、特异性、阳性预测值和阴性预测值分别为89．6％、86．0％、84．93％和94．68％。急性心肌梗死（AMI）组患者的血清中 IMA 水平明显高于健康对照组（P ＜0．05）。联合 IMA 和 CK-MB 诊断 ACS敏感性提升至91．5％，此时特异性为71．5％。结论血清 IMA 水平可作为 ACS 早期诊断和危险分层的灵敏指标，联合检测IMA 和 CK-MB 可提高诊断的敏感性。
목적：탐토혈청결혈수식청단백（IMA）재급성관상동맥종합정（ACS）조기진단중적개치。방법검측117례 ACS환자급100례건강체검자혈청중 IMA 급기산격매동공매（CK-MB）수평，분석 IMA 검측대우 ACS 조기진단중적개치。결과당림계치위73．25 U/mL 시，혈청 IMA 검측판단 ACS 적령민도、특이성、양성예측치화음성예측치분별위89．6％、86．0％、84．93％화94．68％。급성심기경사（AMI）조환자적혈청중 IMA 수평명현고우건강대조조（P ＜0．05）。연합 IMA 화 CK-MB 진단 ACS민감성제승지91．5％，차시특이성위71．5％。결론혈청 IMA 수평가작위 ACS 조기진단화위험분층적령민지표，연합검측IMA 화 CK-MB 가제고진단적민감성。
Objective To explore earlier diagnostic value of ischemia modified albumin(IMA)in acute coronary syndrome(ACS) patients.Methods We detected serum IMA and CK-MB in 117 patients with ACS and 100 healthy controls to analyze the diagnos-tic value of IMA in ACS.Results When the critical value of 73.25 U/mL,serum IMA testing determine the ACS of the sensitivity, specific,positive predictive value and negative predictive value of 89.6%,86.0%,84.93% and 86.0% respectively.IMA levels in serum in patients with AMI group was obviously higher than that of healthy control group(P <0.05).Sensitivity could be improved to 91.5% when detected IMA and CK-MB together.And the specific was 71.5%.Conclusion Serum IMA can be used as sensitive index of early diagnosis and risk stratification of ACS.Detecting IMA and CK-MB can improve the diagnostic sensitivity of ACS.