CAJ | 학술논문

目的：探讨血尿酸（SUA）、β2微球蛋白（β2-MG）、脂蛋白（a）[Lp（a）]和 C 反应蛋白（CRP）在老年高血压患者引起早期肾损伤中的临床应用价值。方法根据临床诊断将210例原发性老年高血压患者作为研究对象和50例健康老年人作为健康对照，分别测定其 SUA、β2-MG、Lp（a）和 CRP 水平并进行统计分析；根据内生肌酐清除率（Cr）将这210例高血压患者又分单纯高血压组和高血压肾病组，观察这4项指标的变化情况。结果高血压组 SUA、β2-MG、Lp（a）和 CRP 水平明显升高且高于对照组，差异有统计学意义（P ＜0．05）。根据血压升高程度分组研究：高血压1级，高血压2级，高血压3级组的 SUA、β2-MG、Lp（a）和 CRP 水平呈趋势性升高，差异有统计学意义（P ＜0．05）；高血压肾病组与单纯高血压组比较：SUA、β2-MG、LP（a）和 CRP 水平显著升高，差异有统计学意义（P ＜0．05）。结论监测老年高血压患者 SUA、β2-MG、LP（a）和 CRP 水平，可有效监测老年高血压患者肾功能的早期受损，可更快地、更有效发现其患者的肾脏病变，有利于临床医生早期对其进行诊治。
목적：탐토혈뇨산（SUA）、β2미구단백（β2-MG）、지단백（a）[Lp（a）]화 C 반응단백（CRP）재노년고혈압환자인기조기신손상중적림상응용개치。방법근거림상진단장210례원발성노년고혈압환자작위연구대상화50례건강노년인작위건강대조，분별측정기 SUA、β2-MG、Lp（a）화 CRP 수평병진행통계분석；근거내생기항청제솔（Cr）장저210례고혈압환자우분단순고혈압조화고혈압신병조，관찰저4항지표적변화정황。결과고혈압조 SUA、β2-MG、Lp（a）화 CRP 수평명현승고차고우대조조，차이유통계학의의（P ＜0．05）。근거혈압승고정도분조연구：고혈압1급，고혈압2급，고혈압3급조적 SUA、β2-MG、Lp（a）화 CRP 수평정추세성승고，차이유통계학의의（P ＜0．05）；고혈압신병조여단순고혈압조비교：SUA、β2-MG、LP（a）화 CRP 수평현저승고，차이유통계학의의（P ＜0．05）。결론감측노년고혈압환자 SUA、β2-MG、LP（a）화 CRP 수평，가유효감측노년고혈압환자신공능적조기수손，가경쾌지、경유효발현기환자적신장병변，유리우림상의생조기대기진행진치。
Objective To explore the clinical application value of blood uric acid(SUA),beta 2 microglobulin(β2-MG),lipopro-tein(a)[LP(a)]and C-reactive protein(CRP)in the early renal damage caused by elderly hypertension.Methods According to the clinical diagnosis,210 elderly patients with primary hypertension were selected as the research subjects and 50 healthy elderly per-sons as the healthy control.The SUA,β2-MG,LP(a)and CRP levels were detected.The differences were compared between the groups with the different severity degrees of hypertension and the healthy control group;Furthermore,these 210 cases of hyperten-sion were divided into the simple hypertension group and the hypertensive renal group according to the creatinine clearance rate (Ccr)for observing the changes of the four indicators.Results The blood SUA,β2-MG,LP(a)and CRP levels in the hypertension group were significantly increased,which were higher than those in the normal control group,the differences had statistical signifi-cance(P <0.01);In the study by grouping according to the increase degree of blood pressure:the blood SUA,β2-MG,LP(a)and CRP levels in the three groups of the grade 1,2,3 hypertension were significantly increased,the statistical analysis showed the sig-nificant difference between groups(P <0.05);Compared with the simple hypertension group,the SUA,β2-MG,LP(a)and CRP lev-els were significantly increased compared with the hypertensive renal group,the difference showed the statistical significance(P <0.05).Conclusion Monitoring blood SUA,beta 2-MG,LP(a)and CRP levels in elderly patients with hypertension can effectively monitor the early renal function damage in the patients with senile hypertension,can find the renal lesions more rapidly and effec-tively and is conducive to early diagnosis and treatment in clinic.