CAJ | 학술논문

目的：观察脑梗死患者同型半胱氨酸（Hcy）、脂蛋白 a[Lp（a）]的变化并进行相关性分析。方法测定230例脑梗死患者血清 Hcy、Lp（a）的水平，将检测结果与90例健康对照者进行组间比较和相关性分析。结果脑梗死整体组、Hcy 升高脑梗死组的血清 Hcy 和 Lp（a）水平显著高于健康对照组（P ＜0．01）。Hcy 未升高脑梗死组的血清 Hcy 和 Lp（a）水平与健康对照组比较无统计学意义（P ＞0．05）。脑梗死整体组的血清 Hcy 和 Lp（a）水平与 Hcy 升高脑梗死组比较无统计学意义（P ＞0．05）。脑梗死整体组、Hcy 升高脑梗死组的血清 Hcy 和 Lp（a）水平与 Hcy 未升高组脑梗死组结果比较均有统计学意义（P ＜0．01）。脑梗死整体组的血清 Hcy 与 Lp（a）呈正相关（r＝0．859，P ＜0．01）。结论血清 Hcy、Lp（a）水平升高与脑梗死的发生有密切关系，对脑梗死诊断有一定价值且血清 Hcy 与 Lp（a）呈正相关。
목적：관찰뇌경사환자동형반광안산（Hcy）、지단백 a[Lp（a）]적변화병진행상관성분석。방법측정230례뇌경사환자혈청 Hcy、Lp（a）적수평，장검측결과여90례건강대조자진행조간비교화상관성분석。결과뇌경사정체조、Hcy 승고뇌경사조적혈청 Hcy 화 Lp（a）수평현저고우건강대조조（P ＜0．01）。Hcy 미승고뇌경사조적혈청 Hcy 화 Lp（a）수평여건강대조조비교무통계학의의（P ＞0．05）。뇌경사정체조적혈청 Hcy 화 Lp（a）수평여 Hcy 승고뇌경사조비교무통계학의의（P ＞0．05）。뇌경사정체조、Hcy 승고뇌경사조적혈청 Hcy 화 Lp（a）수평여 Hcy 미승고조뇌경사조결과비교균유통계학의의（P ＜0．01）。뇌경사정체조적혈청 Hcy 여 Lp（a）정정상관（r＝0．859，P ＜0．01）。결론혈청 Hcy、Lp（a）수평승고여뇌경사적발생유밀절관계，대뇌경사진단유일정개치차혈청 Hcy 여 Lp（a）정정상관。
Objective To observe the change of homocysteine(Hcy)and lipoprotein-a[Lp(a)]of cerebral infarction patients and perform the correlation analysis on them.Methods The serum Hcy and Lp(a)levels were detected in 230 patients with cerebral in-farction and 90 healthy controls.The detection results were performed the comparison between the groups and the correlation analy-sis.Results The serum Hcy and Lp(a)levels in the overall cerebral infarction group and the cerebral infarction group with in-creased Hcy were significantly higher than those in the healthy controls(P <0.01).The serum Hcy and Lp(a)levels in the cerebral infarction group without increased serum Hcy had no statistical difference compared with the healthy control group(P >0.05).The serum Hcy and Lp(a)levels in the overall cerebral infarction group had no statistical difference compared with the cerebral infarc-tion group with increased Hcy(P >0.05).The serum Hcy and Lp(a)levels in the overall cerebral infarction group and the cerebral infarction group with increased Hcy had statistical difference compared with the cerebral infarction group without increased Hcy (P <0.01).The serum Hcy in the overall cerebral infarction group is positively correlated with Lp(a)(r =0.859,P <0.01).Con-clusion The increase of serum Hcy and Lp(a)levels is closely related with the occurrence of cerebral infarction and has certain val-ue in the diagnosis of cerebral infarction,moreover serum Hcy is positively correlated with Lp(a).