CAJ | 학술논문

目的：探讨同型半胱氨酸（Hcy）、一氧化氮合成酶（NOS）及可溶性血栓调节蛋白（STM）在急性脑梗死（ACI）疾病中水平变化及临床意义。方法检测150例 ACI 患者及50例健康成人血清标本中的 Hcy、NOS 及 STM 水平并进行显著性检验及相关性分析。结果与健康对照组比较，ACI 患者 Hcy、NOS 及 STM 结果明显偏高，差异有统计学意义（P ＜0．05）。ACI 患者血清 NOS、STM 升高水平与 Hcy 升高水平呈正相关。结论 Hcy、NOS 及 STM 是 ACI 发生内皮损伤的标志物，检测其平对判断病情、指导治疗具有一定意义。
목적：탐토동형반광안산（Hcy）、일양화담합성매（NOS）급가용성혈전조절단백（STM）재급성뇌경사（ACI）질병중수평변화급림상의의。방법검측150례 ACI 환자급50례건강성인혈청표본중적 Hcy、NOS 급 STM 수평병진행현저성검험급상관성분석。결과여건강대조조비교，ACI 환자 Hcy、NOS 급 STM 결과명현편고，차이유통계학의의（P ＜0．05）。ACI 환자혈청 NOS、STM 승고수평여 Hcy 승고수평정정상관。결론 Hcy、NOS 급 STM 시 ACI 발생내피손상적표지물，검측기평대판단병정、지도치료구유일정의의。
Objective To investigate the level change and the significance of serum homocysteine(Hcy),endothelial nitric oxide synthase(NOS)and soluble thrombomodulin(STM)in the patients with acute cerebral infarction(ACI).Methods The values of serum Hcy,NOS and STM were detected in the 150 patients with ACI and the 50 healthy individuals and the detection results were performed the significance testing and the correlation analysis.Results Compared with the normal control group,the levels of ser-um Hcy,NOS and STM in the ACI patients were significantly increased with statistical differences(P <0.05).The increased level of NOS and HCY in the ACI patients was positively correlated with the increased Hcy level.Conclusion Hcy,NOS and STM are the markers of endothelial injury occurrence and their detection has certain significance for judging the disease condition and guiding treatment.