CAJ | 학술논문

目的：了解铜绿假单胞菌的临床分布及耐药性特性。方法对医院2007年7月至2008年10月细菌培养和药敏试验的结果进行回顾性分析。结果共分离铜绿假单胞菌335株，占总病原菌9．2％；主要标本来源是痰液，占77．6％。高发病区是 ICU 病房。铜绿假单胞菌对丁胺卡那霉素、哌拉西林/他唑巴坦、妥布霉素、左氧氟沙星、头孢吡肟、庆大霉素、替卡西林及环丙沙星12种常用抗菌药物耐药率小于10％。对亚胺培南不敏感的铜绿假单胞菌对氨曲南、头孢他啶、环丙沙星、左氧氟沙星、哌拉西林/他唑巴坦的耐药率明显高于对亚胺培南敏感的铜绿假单胞菌（P ＜0．05）。结论铜绿假单胞菌多重耐药现象普遍存在，建议治疗选用丁胺卡那霉素、哌拉西林/他唑巴坦、妥布霉素。
목적：료해동록가단포균적림상분포급내약성특성。방법대의원2007년7월지2008년10월세균배양화약민시험적결과진행회고성분석。결과공분리동록가단포균335주，점총병원균9．2％；주요표본래원시담액，점77．6％。고발병구시 ICU 병방。동록가단포균대정알잡나매소、고랍서림/타서파탄、타포매소、좌양불사성、두포필우、경대매소、체잡서림급배병사성12충상용항균약물내약솔소우10％。대아알배남불민감적동록가단포균대안곡남、두포타정、배병사성、좌양불사성、고랍서림/타서파탄적내약솔명현고우대아알배남민감적동록가단포균（P ＜0．05）。결론동록가단포균다중내약현상보편존재，건의치료선용정알잡나매소、고랍서림/타서파탄、타포매소。
Objective To investigate the clinical distribution and the drug resistance characteristics of Pseudomonas aeruginosa . Methods The results of the bacterial culture and the antimicrobial susceptibility test in the hospital from July 2007 to October 2008 were performed the retrospective analysis.Results Totally 335 strains of Pseudomonas aeruginosa were isolated,accounting for 9.2% of isolated pathogenic bacteria.The main specimen source was sputum,accounting for 77.6%.The ICU ward was the high incidence area.The resistance rates of Pseudomonas aeruginosa to amikacin,piperacillin/tazobactam,tobramycin,levofloxacin, cefepime,gentamicin,ticarcillin and ciprofloxacin were less than 10%.The resistance rates of imipenem-insensitive Pseudomonas aeruginosa to aztreonam,ceftazidime,ciprofloxacin,levofloxacin,piperacillin/tazobzctam were significantly higher than those in imi-penem-sensitive Pseudomonas aeruginosa (P <0.05).Conclusion The multiple drug resistance phenomena of Pseudomonas aerugi-nosa generally exist,amikacin,piperacillin/tazobactam and tobramycin are recommended for the treatment of infections caused by Pseudomonas aeruginosa .