国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2014年
16期
2135-2136,2138
,共3页
鼻咽癌%潜伏膜蛋白%诊断
鼻嚥癌%潛伏膜蛋白%診斷
비인암%잠복막단백%진단
nasopharyngeal carcinoma%latent membrane protein%diagnosis
目的：探讨潜伏膜蛋白1（LMP-1）基因检测对鼻咽癌（NPC）的诊断价值。方法通过计算机检索及手工查询全面收集采用 PCR 技术检测鼻咽拭子分泌物中的 LMP-1基因诊断 NPC 的相关研究。两名评价者按照纳入排除标准筛选文献，采用QUADAS 量表进行质量评价，采用 Meta-Disc1．4软件进行异质性检验，根据异质性特点选择相应效应模型合并敏感度、特异性并绘制综合受试者工作特性曲线（SROC）。结果共检索到相关文献139篇，最终纳入6篇。经过病理金标准确诊 NPC 患者394例，对照组802例。LMP-1基因诊断 NPC 的汇总灵敏度、特异性分别为0．90[95％CI （0．87，0．93）]、0．98[95％CI （0．96，0．99）]。SROC 曲线下面积（AUC）为0．9737。结论 LMP-1基因对 NPC 具有较高的诊断价值，可用于 NPC 的筛查及辅助诊断。
目的：探討潛伏膜蛋白1（LMP-1）基因檢測對鼻嚥癌（NPC）的診斷價值。方法通過計算機檢索及手工查詢全麵收集採用 PCR 技術檢測鼻嚥拭子分泌物中的 LMP-1基因診斷 NPC 的相關研究。兩名評價者按照納入排除標準篩選文獻，採用QUADAS 量錶進行質量評價，採用 Meta-Disc1．4軟件進行異質性檢驗，根據異質性特點選擇相應效應模型閤併敏感度、特異性併繪製綜閤受試者工作特性麯線（SROC）。結果共檢索到相關文獻139篇，最終納入6篇。經過病理金標準確診 NPC 患者394例，對照組802例。LMP-1基因診斷 NPC 的彙總靈敏度、特異性分彆為0．90[95％CI （0．87，0．93）]、0．98[95％CI （0．96，0．99）]。SROC 麯線下麵積（AUC）為0．9737。結論 LMP-1基因對 NPC 具有較高的診斷價值，可用于 NPC 的篩查及輔助診斷。
목적：탐토잠복막단백1（LMP-1）기인검측대비인암（NPC）적진단개치。방법통과계산궤검색급수공사순전면수집채용 PCR 기술검측비인식자분비물중적 LMP-1기인진단 NPC 적상관연구。량명평개자안조납입배제표준사선문헌，채용QUADAS 량표진행질량평개，채용 Meta-Disc1．4연건진행이질성검험，근거이질성특점선택상응효응모형합병민감도、특이성병회제종합수시자공작특성곡선（SROC）。결과공검색도상관문헌139편，최종납입6편。경과병리금표준학진 NPC 환자394례，대조조802례。LMP-1기인진단 NPC 적회총령민도、특이성분별위0．90[95％CI （0．87，0．93）]、0．98[95％CI （0．96，0．99）]。SROC 곡선하면적（AUC）위0．9737。결론 LMP-1기인대 NPC 구유교고적진단개치，가용우 NPC 적사사급보조진단。
Objective To assess the diagnostic value of the latent membrane protein 1(LMP-1)gene detection for diagnosing na-sopharyngeal carcinoma(NPC).Methods The related researches on the detection of LMP-1 gene in the nasopharyngeal swab secre-tion for diagnosing NPC by PCR were entirely collected by using the computer retrieval or manual inquiring.Two estimators screened the literature according to the criteria of inclusion and exclusion.The quality evaluation was performed by adopting the QUADAS scale.The heterogeneity test was conducted by using Meta-Disc 1.4 software.According to the heterogeneous character-istics,the corresponding effect model was selected for calculating the pooled sensitivity and specificity and the summary receiver op-erating character(SROC)curve was drawn.Results 139 related articles were retrieved,in which 6 articles were finally included. 394 cases of NPC were definitely diagnosed by the pathological golden standard,802 cases were in the control group.The pooled sensitivity and specificity of the LMP-1 gene for diagnosing NPC were 0.90[95%CI (0.87,0.93)]and 0.98[95%CI (0.96,0.99)] respectively.The area under SROC(AUC)was 0.973 7.Conclusion LMP-1 gene has the higher diagnostic value for NPC and could be used for screening and auxiliary diagnosis of NPC.
