CAJ | 학술논문

目的：探讨寻常型和节段型白癜风CD分子表达的差异。方法应用免疫组织化学方法检测CD3、CD4、CD8、CD20、CD45RO、CD68和CD79α在白癜风皮损中的表达。结果寻常型与节段型白癜风皮损中 CD3、CD4、CD8和CD45RO浸润细胞数均明显高于正常对照组，差异有统计学意义（P﹤0.01）；寻常型及节段型白癜风皮损中CD20、CD79α和CD68浸润细胞数与正常对照组比较差异无统计学意义（ P﹥0.01）。结论寻常型与节段型白癜风存在CD3、CD4、CD8及CD45RO的免疫参与，可能与白癜风的免疫发病机制有关。
목적：탐토심상형화절단형백전풍CD분자표체적차이。방법응용면역조직화학방법검측CD3、CD4、CD8、CD20、CD45RO、CD68화CD79α재백전풍피손중적표체。결과심상형여절단형백전풍피손중 CD3、CD4、CD8화CD45RO침윤세포수균명현고우정상대조조，차이유통계학의의（P﹤0.01）；심상형급절단형백전풍피손중CD20、CD79α화CD68침윤세포수여정상대조조비교차이무통계학의의（ P﹥0.01）。결론심상형여절단형백전풍존재CD3、CD4、CD8급CD45RO적면역삼여，가능여백전풍적면역발병궤제유관。
Objective To investigate the differences of CDs infiltrating cells expressions in seg-mental and non-segmental vitiligo. Methods The expressions of CD3,CD4,CD8,CD20,CD45RO, CD68,CD79a were detected by immunohistochemical staining. Results The expressions of CD3 , CD4 ,CD8 and CD45 RO of the infiltrating cells in both non-segmental and segmental vitiligo were significantly higher than those of normal control group,the differences were statistically significant ( P﹤0. 01 );the expressions of CD20 ,CD79αand CD68 of infiltrating cells both in segmental and non-segmental vitiligo were same as normal control group,the difference was not statistically signifi-cant( P﹥0. 01 ). Conclusions CD3 ,CD4 ,CD8 ,CD45 RO and CD68 are related to immune re-sponse both in segmental and non-segmental vitiligo.