中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2014年
18期
34-36
,共3页
沙美特罗%丙酸氟替卡松%儿童%中度%支气管哮喘%呼气峰流速占比%外周血嗜酸粒细胞计数
沙美特囉%丙痠氟替卡鬆%兒童%中度%支氣管哮喘%呼氣峰流速佔比%外週血嗜痠粒細胞計數
사미특라%병산불체잡송%인동%중도%지기관효천%호기봉류속점비%외주혈기산립세포계수
Salmeterol%Fluticasone propionate%Children%Moderate%Bronchial asthma%Peak expiratory flow accounting%Peripheral blood eosinophil counts
目的：研究沙美特罗（ SM）联合丙酸氟替卡松（ FP）对儿童中度支气管哮喘（ BA）患儿呼气峰流速（ PEF）占预计值百分比、外周血嗜酸粒细胞计数（ PBEC）等水平变化的影响。方法选择2012年2月至2013年2月郑州大学附属洛阳中心医院66例确诊为中度BA患儿，以数字法随机分成观察组和对照组，每组33例。对照组以布地奈德治疗，观察组则以SM联合FP（即舒利迭）治疗。对比两组治疗前后PEF占预计值的百分比及PBEC水平情况以及疗效。结果观察组治疗后PEF占预计值的百分比为（81±4）%，显著高于治疗前的（67±3）%以及对照组治疗后的（76±4）%；观察组治疗后的PBEC水平为（544±91）×106/L，显著低于治疗前的（762±87）×106/L以及对照组治疗后的（592±82）×106/L；观察组总有效率为93.94%，显著高于对照组的69.70%；差异均有统计学意义（ P均﹤0.05）。结论 SM联合FP药物治疗中度BA患儿可明显提升疗效，改善患儿肺部功能，效果显著，值得临床推荐。
目的：研究沙美特囉（ SM）聯閤丙痠氟替卡鬆（ FP）對兒童中度支氣管哮喘（ BA）患兒呼氣峰流速（ PEF）佔預計值百分比、外週血嗜痠粒細胞計數（ PBEC）等水平變化的影響。方法選擇2012年2月至2013年2月鄭州大學附屬洛暘中心醫院66例確診為中度BA患兒，以數字法隨機分成觀察組和對照組，每組33例。對照組以佈地奈德治療，觀察組則以SM聯閤FP（即舒利迭）治療。對比兩組治療前後PEF佔預計值的百分比及PBEC水平情況以及療效。結果觀察組治療後PEF佔預計值的百分比為（81±4）%，顯著高于治療前的（67±3）%以及對照組治療後的（76±4）%；觀察組治療後的PBEC水平為（544±91）×106/L，顯著低于治療前的（762±87）×106/L以及對照組治療後的（592±82）×106/L；觀察組總有效率為93.94%，顯著高于對照組的69.70%；差異均有統計學意義（ P均﹤0.05）。結論 SM聯閤FP藥物治療中度BA患兒可明顯提升療效，改善患兒肺部功能，效果顯著，值得臨床推薦。
목적：연구사미특라（ SM）연합병산불체잡송（ FP）대인동중도지기관효천（ BA）환인호기봉류속（ PEF）점예계치백분비、외주혈기산립세포계수（ PBEC）등수평변화적영향。방법선택2012년2월지2013년2월정주대학부속락양중심의원66례학진위중도BA환인，이수자법수궤분성관찰조화대조조，매조33례。대조조이포지내덕치료，관찰조칙이SM연합FP（즉서리질）치료。대비량조치료전후PEF점예계치적백분비급PBEC수평정황이급료효。결과관찰조치료후PEF점예계치적백분비위（81±4）%，현저고우치료전적（67±3）%이급대조조치료후적（76±4）%；관찰조치료후적PBEC수평위（544±91）×106/L，현저저우치료전적（762±87）×106/L이급대조조치료후적（592±82）×106/L；관찰조총유효솔위93.94%，현저고우대조조적69.70%；차이균유통계학의의（ P균﹤0.05）。결론 SM연합FP약물치료중도BA환인가명현제승료효，개선환인폐부공능，효과현저，치득림상추천。
Objective To study the effects of Salmeterol( SM ) combined with fluticasone propionate( FP)on PEF rate,PBEC of children patients with bronchial asthma( BA). Meth-ods From February 2012 to February 2013,a total of 66 children were chose with moderate BA. They were digital randomly divided into the observation group(33 cases)and the control group(33 cases). The control group was treated with budesonide,and the observation group was treated with SM combined with FP. The PEF accounting rate and PBEC levels before and after treatment,as well as the efficacy of the situation. Results After treatment,PEF of the observation group accounted for(81 ± 4)%,which was significantly higher than that before treatment(67 ± 3)% and the control group after treatment(76 ± 4 )%. The PBEC( × 106/L)level was 544 ± 91 after treatment in the observation,which was significant-ly less than that before treatment(762 ± 87),and that of the control group after treatment was 592 ± 82. The total effective rate was 93. 94%in the observation group,which was significantly higher than that of the control group(69. 70%). The differences were all significant(P﹤0. 05). Conclusions SM com-bined with FP drugs for the treatment of moderate BA children,can not only significantly improve the ef-ficacy,but also improve the lung function of children. The effect is significant,which is worthy of recom-mendation.
