CAJ | 학술논문

目的：探讨卡维地洛对慢性心力衰竭患者血浆脑钠肽（ BNP）、左心功能的影响及临床疗效。方法将2011年8月至2013年3月收治的64例慢性充血性心力衰竭患者随机分为观察组和对照组，各32例。对照组给予常规治疗，观察组在常规治疗基础上加用卡维地洛。比较两组患者临床疗效及治疗前、后左心功能和血浆BNP水平。结果治疗6个月后对照组总有效率为78.1%，观察组总有效率为93.8%，差异有统计学意义（ P﹤0.05）；治疗3、6个月后两组患者血浆BNP、左心室舒张末内径（ LVEDD）、左心室收缩末内径（ LVSDD）较治疗前下降，左心室射血分数（LVEF）较治疗前增加（P﹤0.05）；观察组患者血浆BNP、LVEDD、LVSDD下降幅度，LVEF改善情况均明显优于对照组，差异有统计学意义（P﹤0.05）。结论卡维地洛辅助治疗慢性充血性心力衰竭临床疗效较好，可有效拮抗神经内分泌，改善左心功能及患者预后。
목적：탐토잡유지락대만성심력쇠갈환자혈장뇌납태（ BNP）、좌심공능적영향급림상료효。방법장2011년8월지2013년3월수치적64례만성충혈성심력쇠갈환자수궤분위관찰조화대조조，각32례。대조조급여상규치료，관찰조재상규치료기출상가용잡유지락。비교량조환자림상료효급치료전、후좌심공능화혈장BNP수평。결과치료6개월후대조조총유효솔위78.1%，관찰조총유효솔위93.8%，차이유통계학의의（ P﹤0.05）；치료3、6개월후량조환자혈장BNP、좌심실서장말내경（ LVEDD）、좌심실수축말내경（ LVSDD）교치료전하강，좌심실사혈분수（LVEF）교치료전증가（P﹤0.05）；관찰조환자혈장BNP、LVEDD、LVSDD하강폭도，LVEF개선정황균명현우우대조조，차이유통계학의의（P﹤0.05）。결론잡유지락보조치료만성충혈성심력쇠갈림상료효교호，가유효길항신경내분비，개선좌심공능급환자예후。
Objective To investigate the effects of carvedilol on the plasma brain natriuretic peptide( BNP)level and left heart function in patients with chronic heart failure and its clinical efficacy. Methods From August 2011 to Match 2013 ,64 patients with chronic heart failure were randomly divid-ed into observation group and control group,each group with 32 patients. Patients in the control group were treated with conventional therapy,and patients in the observation group were treated with carvedilol on the basis of conventional therapy. The left heart function,plasma BNP levels in the two groups before and after treatment,and the clinical effects were compared. Results After 6 months of treatment,the total effective rate was 78. 1% in the control group,and that was 93. 8% in the observation group,there was significant difference( P﹤0. 05 ). The plasma BNP,LVEDD,LVSDD levels in the two groups re-duced,but the LVEF level increased after 3,6 months of treatment(P﹤0. 05). The observation group was superior to the control group in decreasing the levels of BNP,LVEDD,LVSDD and elevating the lev-el of LVEF,there were significant differences(P﹤0. 05). Conclusions The clinical effect of carvedilol adjuvant therapy on chronic congestive heart failure is good,it can countermeasure the neuroendocrine ef-fectively and improve the left heart function and the prognosis of patients.