中国实用神经疾病杂志
中國實用神經疾病雜誌
중국실용신경질병잡지
CHINESE JOURNAL OF PRACTICAL NERVOUS DISEASES
2014年
17期
34-35
,共2页
帕金森病%抑郁%文拉法辛%认知疗法%安全性%有效性
帕金森病%抑鬱%文拉法辛%認知療法%安全性%有效性
파금삼병%억욱%문랍법신%인지요법%안전성%유효성
Parkinson's disease%Depression%Venlafaxine%Cognitive therapy%Safty%Effectiveness
目的：分析文拉法辛联合认知疗法治疗帕金森病抑郁的临床疗效和安全性。方法选取我院收治的100例帕金森病合并抑郁症患者为研究对象，随机分为试验组和对照组，每组50例，对照组口服盐酸文拉法辛胶囊，试验组口服盐酸文拉法辛胶囊联合认知行为治疗，分别在治疗前及治疗后2、4、8、12周采用汉密尔顿抑郁量表（HAMD）对其抑郁程度进行评分，蒙特利尔认知评估表评价其生活质量，密切观察不良反应。结果相比治疗前，2组治疗后 HAMD评分及蒙特利尔认知评分显著降低，差异有统计学意义（P＜0.05）；相比对照组，实验组治疗后 HAMD评分及蒙特利尔认知评分显著降低，差异有统计学意义（P＜0.05）。结论文拉法辛联合认知行为治疗帕金森病合并抑郁症安全有效，明显改善患者生活质量，值得临床推广。
目的：分析文拉法辛聯閤認知療法治療帕金森病抑鬱的臨床療效和安全性。方法選取我院收治的100例帕金森病閤併抑鬱癥患者為研究對象，隨機分為試驗組和對照組，每組50例，對照組口服鹽痠文拉法辛膠囊，試驗組口服鹽痠文拉法辛膠囊聯閤認知行為治療，分彆在治療前及治療後2、4、8、12週採用漢密爾頓抑鬱量錶（HAMD）對其抑鬱程度進行評分，矇特利爾認知評估錶評價其生活質量，密切觀察不良反應。結果相比治療前，2組治療後 HAMD評分及矇特利爾認知評分顯著降低，差異有統計學意義（P＜0.05）；相比對照組，實驗組治療後 HAMD評分及矇特利爾認知評分顯著降低，差異有統計學意義（P＜0.05）。結論文拉法辛聯閤認知行為治療帕金森病閤併抑鬱癥安全有效，明顯改善患者生活質量，值得臨床推廣。
목적：분석문랍법신연합인지요법치료파금삼병억욱적림상료효화안전성。방법선취아원수치적100례파금삼병합병억욱증환자위연구대상，수궤분위시험조화대조조，매조50례，대조조구복염산문랍법신효낭，시험조구복염산문랍법신효낭연합인지행위치료，분별재치료전급치료후2、4、8、12주채용한밀이돈억욱량표（HAMD）대기억욱정도진행평분，몽특리이인지평고표평개기생활질량，밀절관찰불량반응。결과상비치료전，2조치료후 HAMD평분급몽특리이인지평분현저강저，차이유통계학의의（P＜0.05）；상비대조조，실험조치료후 HAMD평분급몽특리이인지평분현저강저，차이유통계학의의（P＜0.05）。결논문랍법신연합인지행위치료파금삼병합병억욱증안전유효，명현개선환자생활질량，치득림상추엄。
Objective To study the clinical efficacy and safety of venlafaxine plus cognitive therapy for depression in Par-kinson's disease .Methods One hundred cases of Parkinson's disease patients with depression treated in hospital were selected as the research object ,and were randomly divided into experimental group and control group ,50 cases in each group ,the con-trol group took venlafaxine hydrochloride capsules ,the experimental group was given venlafaxine hydrochloride capsules com-bined with cognitive behavior therapy .Before and after treatment for 2 weeks ,4 weeks ,8 weeks ,12 weeks ,the Hamilton de-pression scale (HAMD) was used to evaluate their degree of depression ,Montreal cognitive evaluation form to evaluate their quality of life ,and adverse reactions were closely observed .Results HAMD score and Montreal cognitive scores were signifi-cantly lower than those before treatment ,the difference was statistically significant (P<0 .05);compared to the control group , after treatment ,HAMD scores and Montreal cognitive scores of the experimental group were significantly reduced ,and the difference was statistically significant (P<0 .05) .Conclusion Venlafaxine plus cognitive behavioral therapy for the treatment of depression in Parkinson disease patients is safe and effective ,and can improve the quality of life of patients ,it should be spreaded in clinical applications .
