CAJ | 학술논문

目的：探讨早期类风湿关节炎(RA)患者病情活动期血清脂质代谢紊乱发生率及其影响因素。方法2011年1月-2012年12月收治的50例病情活动期未用激素以及免疫调节药物治疗的早期RA患者进行总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白Al(apoAI)、载脂蛋白B(aPoB)、脂蛋白(a)=LP(a)检测，观察RA患者活动期血清脂质代谢特点。结果①病情活动期未经治疗RA患者中发生血症代谢异常总例数是45例，占90%，异常的发生率分别是：高LP(a)血症为68%、低apoAI 血症为40%、低HDL-C 血症为30%、高 TG 血症为22%、高 apoB 血症为22%、高TC血症为16%、高LDL-C血症为16%。②早期RA病情活动期42例女性患者与8例男性患者于血脂差异无显著性；③早期RA病情活动期Tc、LDL-C、apoB与年龄、BMI呈正相关；TG与BMI呈正相关；HDL-C与CRP、DAS28呈负相关， apoAI与DAs28呈负相关。结论 RA患者血脂异常影响着AS的发生而发展，年龄、病程、BMI等因素影响着RA的预后，早期诊断、早期治疗是减轻RA危害的重要措施。
목적：탐토조기류풍습관절염(RA)환자병정활동기혈청지질대사문란발생솔급기영향인소。방법2011년1월-2012년12월수치적50례병정활동기미용격소이급면역조절약물치료적조기RA환자진행총담고순(TC)、감유삼지(TG)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C)、재지단백Al(apoAI)、재지단백B(aPoB)、지단백(a)=LP(a)검측，관찰RA환자활동기혈청지질대사특점。결과①병정활동기미경치료RA환자중발생혈증대사이상총례수시45례，점90%，이상적발생솔분별시：고LP(a)혈증위68%、저apoAI 혈증위40%、저HDL-C 혈증위30%、고 TG 혈증위22%、고 apoB 혈증위22%、고TC혈증위16%、고LDL-C혈증위16%。②조기RA병정활동기42례녀성환자여8례남성환자우혈지차이무현저성；③조기RA병정활동기Tc、LDL-C、apoB여년령、BMI정정상관；TG여BMI정정상관；HDL-C여CRP、DAS28정부상관， apoAI여DAs28정부상관。결론 RA환자혈지이상영향착AS적발생이발전，년령、병정、BMI등인소영향착RA적예후，조기진단、조기치료시감경RA위해적중요조시。
Objective To investigate the early rheumatoid arthritis (RA) disease activity in patients with abnormal serum lipid metabolism and associated factors . Methods from January 2011 to December 2012 were treated 50 cases of active disease not use hormones and early RA patients treated with immunomodulatory drugs observation of serum lipids in patients with active RA qualitative metabolic characteristics . Results (1) disease activity of untreated abnormal metabolic acidosis total number of cases occurred in patients with RA in 45 cases, accounting for 90% incidence of abnormalities were: high LP (a) 68% hypertriglyc-eridemia , low blood apoAI disease was 40% , low HDL-C viremia was 30% , 22% high TG hyperlipidemia , hypertriglyceridemia high apoB was 22%, 16%higher TC hyperlipidemia , high LDL-C viremia was 16%. ( 2 ) early RA disease activity of 42 cases of female patients and eight cases of male patients on lipid difference was not statistically significant;( 3 ) early RA disease activ-ity of Tc, LDL-C, apoB and age , BMI was positively correlated ; TG and BMI was positively relevant ; HDL-C and CRP, DAS28 was negatively correlated , apoAI negatively correlated with DAs28. Conclusion RA patients with abnormal blood lipids affect the occurrence and development of AS , age, duration , BMI and other factors affecting the prognosis of RA , early diagnosis , early treatment is an important measure to reduce the RA hazards