中国医药导报
中國醫藥導報
중국의약도보
CHINA MEDICAL HERALD
2014年
23期
80-82,86
,共4页
同型半胱氨酸%超敏C反应蛋白%动脉粥样硬化性心血管疾病
同型半胱氨痠%超敏C反應蛋白%動脈粥樣硬化性心血管疾病
동형반광안산%초민C반응단백%동맥죽양경화성심혈관질병
Homocysteine%High sensitivity C-reactive protein%Atherosclerotic cardiovascular diseases
目的：探讨同型半胱氨酸(Hcy)和超敏C反应蛋白(hs-CRP)作为心血管疾病的常规筛查指标，在正常人群健康体检中的意义。方法选择2012年6~12月在北京军区总医院体检中心接收健康体检者512例为体检组，另取100份正常健康人混合血清为正常对照组，均进行Hcy和hs-CRP的测定。结果①正常对照组Hcy值为(9.2±0.4)μmol/L，hs-CRP值为(0.58±0.04)mg/L。②体检组血清Hcy值为(12.2±2.5)μmol/L，高于正常对照组混合血清Hcy值，差异有统计学意义(P<0.05)；其中有60例高于正常值，异常率为11.7%。③体检组血清hs-CRP值为(0.87±0.32)mg/L，与正常对照组混合血清hs-CRP值比较，差异有统计学意义(P<0.05)；其中93例高于正常值，异常率为18.1%。④血清Hcy及hs-CRP同时检测的ACVD检出率为30.0%，高于单纯Hcy检测的23.3%和单纯hs-CRP检测的15.1%。结论无论Hcy还是hs-CRP，在对动脉粥样硬化性心血管疾病进行诊断、评估时都是独立的指标，二者同时进行检测意义更大。
目的：探討同型半胱氨痠(Hcy)和超敏C反應蛋白(hs-CRP)作為心血管疾病的常規篩查指標，在正常人群健康體檢中的意義。方法選擇2012年6~12月在北京軍區總醫院體檢中心接收健康體檢者512例為體檢組，另取100份正常健康人混閤血清為正常對照組，均進行Hcy和hs-CRP的測定。結果①正常對照組Hcy值為(9.2±0.4)μmol/L，hs-CRP值為(0.58±0.04)mg/L。②體檢組血清Hcy值為(12.2±2.5)μmol/L，高于正常對照組混閤血清Hcy值，差異有統計學意義(P<0.05)；其中有60例高于正常值，異常率為11.7%。③體檢組血清hs-CRP值為(0.87±0.32)mg/L，與正常對照組混閤血清hs-CRP值比較，差異有統計學意義(P<0.05)；其中93例高于正常值，異常率為18.1%。④血清Hcy及hs-CRP同時檢測的ACVD檢齣率為30.0%，高于單純Hcy檢測的23.3%和單純hs-CRP檢測的15.1%。結論無論Hcy還是hs-CRP，在對動脈粥樣硬化性心血管疾病進行診斷、評估時都是獨立的指標，二者同時進行檢測意義更大。
목적：탐토동형반광안산(Hcy)화초민C반응단백(hs-CRP)작위심혈관질병적상규사사지표，재정상인군건강체검중적의의。방법선택2012년6~12월재북경군구총의원체검중심접수건강체검자512례위체검조，령취100빈정상건강인혼합혈청위정상대조조，균진행Hcy화hs-CRP적측정。결과①정상대조조Hcy치위(9.2±0.4)μmol/L，hs-CRP치위(0.58±0.04)mg/L。②체검조혈청Hcy치위(12.2±2.5)μmol/L，고우정상대조조혼합혈청Hcy치，차이유통계학의의(P<0.05)；기중유60례고우정상치，이상솔위11.7%。③체검조혈청hs-CRP치위(0.87±0.32)mg/L，여정상대조조혼합혈청hs-CRP치비교，차이유통계학의의(P<0.05)；기중93례고우정상치，이상솔위18.1%。④혈청Hcy급hs-CRP동시검측적ACVD검출솔위30.0%，고우단순Hcy검측적23.3%화단순hs-CRP검측적15.1%。결론무론Hcy환시hs-CRP，재대동맥죽양경화성심혈관질병진행진단、평고시도시독립적지표，이자동시진행검측의의경대。
Objective To discuss the significance of homocysteine (Hcy) and high sensitivity C-reactive protein (hs-CRP) in medical examination of healthy people as the routine determined index. Methods 512 cases of medical exami-nation people in Physical Examination Center of the General Hospital of Beijing Military Command from June to De-cember 2012 were selected as examination group. 100 cases of normal healthy people were chose as normal control group. The Hcy and hs-CRP were all measured in all the cases. Results ①The Hcy and hs-CRP in normal control group was (9.2±0.4)μmol/L and (0.58±0.04) mg/L respectively.②The Hcy in examination group was (12.2±2.5)μmol/L, it was higher than that in normal control group, the difference was statistically significant (P<0.05);there were 60 cases of higher than normal in examination group, the abnormal rate was 11.7%. ③The hs-CRP in examination group was (0.87±0.32) mg/L, compared with normal control group, the difference was statistically significant (P<0.05);there were 93 cases of higher than normal in examination group, the abnormal rate was 18.1%.④The ACVD detection rate by simul-taneous detection of Hcy and hs-CRP was 30.0%, it was higher than that of simple detection of Hcy (23.3%) or hs-CRP (15.1%). Conclusion The Hcy or hs-CRP are the independent indicators for diagnosis and evaluation of the atheroscle-rotic diseases. The significance is bigger by simultaneous detection of Hcy and hs-CRP.
