中国医药导报
中國醫藥導報
중국의약도보
CHINA MEDICAL HERALD
2014年
23期
22-25
,共4页
三唑仑%血药浓度%一阶导数光谱法%治疗药物监测
三唑崙%血藥濃度%一階導數光譜法%治療藥物鑑測
삼서륜%혈약농도%일계도수광보법%치료약물감측
Triazolam%Plasma drug concentration%First order derivative spectrophotometry%Therapeutic drug moni-toring
目的：建立测定人血浆中三唑仑浓度的一阶导数分光光度法，为临床应用提供技术参考。方法采用一阶导数光谱法在232.0 nm波长处测定人血浆中三唑仑浓度。结果三唑仑在2.55~15.30μg/mL范围呈良好线性关系；其回归方程为D=1.3487×10-3C+3.7748×10-3(r =0.9965)；平均回收率为101.53豫，RSD=2.12豫(n=5)。结论该法操作简单，测定结果准确，适用于三唑仑血药浓度的监测。
目的：建立測定人血漿中三唑崙濃度的一階導數分光光度法，為臨床應用提供技術參攷。方法採用一階導數光譜法在232.0 nm波長處測定人血漿中三唑崙濃度。結果三唑崙在2.55~15.30μg/mL範圍呈良好線性關繫；其迴歸方程為D=1.3487×10-3C+3.7748×10-3(r =0.9965)；平均迴收率為101.53豫，RSD=2.12豫(n=5)。結論該法操作簡單，測定結果準確，適用于三唑崙血藥濃度的鑑測。
목적：건립측정인혈장중삼서륜농도적일계도수분광광도법，위림상응용제공기술삼고。방법채용일계도수광보법재232.0 nm파장처측정인혈장중삼서륜농도。결과삼서륜재2.55~15.30μg/mL범위정량호선성관계；기회귀방정위D=1.3487×10-3C+3.7748×10-3(r =0.9965)；평균회수솔위101.53예，RSD=2.12예(n=5)。결론해법조작간단，측정결과준학，괄용우삼서륜혈약농도적감측。
Objective To develop first order derivative spectrophotometry for the determination of Triazolam concentra-tion in human plasma to provide the technical reference for its clinical application. Methods The first order derivative spectrophotometry was performed at the wavelength of 232.0 nm. Results Triazolam showed a good linear relationship within a ranger of 2.55-15.30 μg/mL, the regression equation was D=1.3487í10-3C+3.7748í10-3 (r=0.9965); the aver-age recovery was 101.53%, RSD=2.12%(n=5). Conclusion This method is simple to operate and accurate in the detec-tion results, and can be applied in the analysis of Triazolam in human plasma.
