CAJ | 학술논문

目的：研究宫颈组织中胰岛素样生长因子-1受体（IGF-1R）的分布、表达及 D2-40标记的淋巴管密度（LVD），探寻宫颈鳞癌组织中 IGF-1R 与淋巴结转移之间的联系。方法应用 S-P 免疫组化探寻正常宫颈组织、CIN Ⅲ组织、宫颈鳞癌组织中 IGF-1R 和 D2-40标记的淋巴管密度的表达情况。结果宫颈鳞癌组织中 IGF-1R 阳性表达率与正常宫颈组织、CIN Ⅲ组织比较有差异有统计学意义（P ﹤0.05）。正常宫颈组、CIN Ⅲ组织和宫颈鳞癌淋巴管密度比较差异有统计学意义（P ﹤0.05）。结论 IGF-1R 在宫颈癌组织淋巴管的生成及淋巴道的转移中可能有促进作用，在预测宫颈鳞癌的预后及临床治疗方面检测 IGF-1R 表达有一定的指导意义。
목적：연구궁경조직중이도소양생장인자-1수체（IGF-1R）적분포、표체급 D2-40표기적림파관밀도（LVD），탐심궁경린암조직중 IGF-1R 여림파결전이지간적련계。방법응용 S-P 면역조화탐심정상궁경조직、CIN Ⅲ조직、궁경린암조직중 IGF-1R 화 D2-40표기적림파관밀도적표체정황。결과궁경린암조직중 IGF-1R 양성표체솔여정상궁경조직、CIN Ⅲ조직비교유차이유통계학의의（P ﹤0.05）。정상궁경조、CIN Ⅲ조직화궁경린암림파관밀도비교차이유통계학의의（P ﹤0.05）。결론 IGF-1R 재궁경암조직림파관적생성급림파도적전이중가능유촉진작용，재예측궁경린암적예후급림상치료방면검측 IGF-1R 표체유일정적지도의의。
Objective To study the expression of IGF-1R and lymphatic vessel density(LVD)marked by D2-40 in cervical tissues,and the relationship between the expression of IGF-1R and lymph node metastasis in squamous carcinoma tissue. Methods Immunohistochemical S-P method was applied to normal cervical tissue,CIN Ⅲ,cervical squamous car-cinoma tissue,and the expression of IGF-1R and the lymphatic vessel density which marked by D2-40 were observed. Re-sults There were significant differences in IGF-1R expression rates between cervical squamous cell carcinoma and normal cervical tissue,CIN Ⅲ(P ﹤ 0. 05). Normal cervix,CIN Ⅲ compared with cervical squamous carcinoma of lymphatic ves-sel density,the differences were significant(P ﹤ 0. 05). Conclusions IGF-1R may have a role in promoting lymphatic genesis and lymphatic metastasis,and may predict the prognosis of cervical squamous cell carcinomas and has certain guid-ing significance in clinical treatment.