CAJ | 학술논문

目的：评价地佐辛超前镇痛对腹腔镜肝切除患者术后疼痛及血清白介素6(IL-6)和白介素10(IL-10)表达的影响。方法50例腹腔镜肝切除术患者，随机分为对照组与观察组，各25例。对照组：腹腔镜肝切除术患者未采取任何超前镇痛。观察组：腹腔镜肝切除术患者采用超前镇痛。结果观察组术后4、8、12、24 h的患者VAS疼痛评分均低于对照组术后4、8、12、24 h的患者VAS疼痛评分，差异有统计学意义(P<0.01)。观察组术后4、8、12、24 h的患者血清IL-6水平及血清IL-10水平均低于对照组术后4、8、12、24 h的患者血清IL-6水平及血清IL-10水平，差异有统计学意义(P<0.01~0.05)。结论腹腔镜肝切除术后患者采用地佐辛进行超前镇痛能有效减轻伤害后疼痛，而且能有效改善患者血清IL-6、IL-10水平，保持机体内部炎性因子与抗炎性因子浓度的平衡，化解术后患者体内的代谢紊乱，降低并发症的发生率。
목적：평개지좌신초전진통대복강경간절제환자술후동통급혈청백개소6(IL-6)화백개소10(IL-10)표체적영향。방법50례복강경간절제술환자，수궤분위대조조여관찰조，각25례。대조조：복강경간절제술환자미채취임하초전진통。관찰조：복강경간절제술환자채용초전진통。결과관찰조술후4、8、12、24 h적환자VAS동통평분균저우대조조술후4、8、12、24 h적환자VAS동통평분，차이유통계학의의(P<0.01)。관찰조술후4、8、12、24 h적환자혈청IL-6수평급혈청IL-10수평균저우대조조술후4、8、12、24 h적환자혈청IL-6수평급혈청IL-10수평，차이유통계학의의(P<0.01~0.05)。결론복강경간절제술후환자채용지좌신진행초전진통능유효감경상해후동통，이차능유효개선환자혈청IL-6、IL-10수평，보지궤체내부염성인자여항염성인자농도적평형，화해술후환자체내적대사문란，강저병발증적발생솔。
Objective To evaluate the effect of dezocine preemptive analgesia on the postoperative pain, serum IL-6 and IL-10 expression of patients with laparoscopic liver resection. Methods 50 patients with laparoscopic liver resection were randomly di-vided into control group and observation group, 25 cases in each. The control group: the patients underwent laparoscopic liver re-section were not given any preemptive analgesia. The observation group: the patients underwent laparoscopic liver resection were given preemptive analgesia. Results The VAS of the observation group 4 h, 8 h, 12 h, 24 h after the operation was lower than that of the control group, respectively, the difference was statistically significant(P<0.01). The level of serum IL-6 and IL-10 of the ob-servation group 4 h, 8 h, 12 h, 24 h after the operation was lower than that of the control group, respectively, the difference was statistically significant(P<0.01~0.05). Conclusion Dezocine preemptive analgesia for patients after laparoscopic liver resection can effectively relieve the pain after injury, improve the level of serum IL-6 and IL-10, maintain the body's internal inflammatory fac-tor and anti-inflammatory factor concentration equilibrium, dissolve the metabolic disorder in patients after operation and reduce the incidence of complications.