中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2014年
21期
23-25
,共3页
骨骼肌疾病%血清转氨酶%肌酸激酶%诊断意义
骨骼肌疾病%血清轉氨酶%肌痠激酶%診斷意義
골격기질병%혈청전안매%기산격매%진단의의
Skeletal muscle disease%Serum transaminase%Creatine kinase%Diagnostic significance
目的：对骨骼肌疾病患者血清转氨酶和肌酸激酶测定的诊断意义进行探讨分析。方法整理分析2012年9月1日-2013年9月1日该院经检测血清转氨酶和肌酸激酶含量升高的123例患者的临床资料，并选取40例身体健康者作为对照。以上163例临床标本可分为骨骼肌损伤组（41例）、心肌损伤组（42例）、肝细胞损伤组（40例）、健康对照组（40例）四组。分别检测其血清转氨酶和肌酸激酶的含量。结果心肌损伤引起的AST变化最大，阳性率为73.16%，明显高于另外骨三组的阳性率，39.02%、45.00%、0.00%；肝损伤组的ALT含量变化最大，其阳性率为80.00%明显高于其余各组的31.70%、28.57%、0.00%；而骨骼肌损伤组引起的AST、ALT、CK含量变化都较为中等，其中CK的阳性率为80.95%高于其他各组的36.59%、5.00%、0.00%。轻度、中度、重度骨骼肌损伤可使得CK的含量达（876±572）、（9875±3420）、（20341±4597）U/L明显高于无损伤的正常人，以上差异有统计学意义（P<0.05）。结论骨骼肌损伤、心肌、及肝细胞损伤性疾病都能导致血清中转氨酸酶及肌酸激酶的变化。
目的：對骨骼肌疾病患者血清轉氨酶和肌痠激酶測定的診斷意義進行探討分析。方法整理分析2012年9月1日-2013年9月1日該院經檢測血清轉氨酶和肌痠激酶含量升高的123例患者的臨床資料，併選取40例身體健康者作為對照。以上163例臨床標本可分為骨骼肌損傷組（41例）、心肌損傷組（42例）、肝細胞損傷組（40例）、健康對照組（40例）四組。分彆檢測其血清轉氨酶和肌痠激酶的含量。結果心肌損傷引起的AST變化最大，暘性率為73.16%，明顯高于另外骨三組的暘性率，39.02%、45.00%、0.00%；肝損傷組的ALT含量變化最大，其暘性率為80.00%明顯高于其餘各組的31.70%、28.57%、0.00%；而骨骼肌損傷組引起的AST、ALT、CK含量變化都較為中等，其中CK的暘性率為80.95%高于其他各組的36.59%、5.00%、0.00%。輕度、中度、重度骨骼肌損傷可使得CK的含量達（876±572）、（9875±3420）、（20341±4597）U/L明顯高于無損傷的正常人，以上差異有統計學意義（P<0.05）。結論骨骼肌損傷、心肌、及肝細胞損傷性疾病都能導緻血清中轉氨痠酶及肌痠激酶的變化。
목적：대골격기질병환자혈청전안매화기산격매측정적진단의의진행탐토분석。방법정리분석2012년9월1일-2013년9월1일해원경검측혈청전안매화기산격매함량승고적123례환자적림상자료，병선취40례신체건강자작위대조。이상163례림상표본가분위골격기손상조（41례）、심기손상조（42례）、간세포손상조（40례）、건강대조조（40례）사조。분별검측기혈청전안매화기산격매적함량。결과심기손상인기적AST변화최대，양성솔위73.16%，명현고우령외골삼조적양성솔，39.02%、45.00%、0.00%；간손상조적ALT함량변화최대，기양성솔위80.00%명현고우기여각조적31.70%、28.57%、0.00%；이골격기손상조인기적AST、ALT、CK함량변화도교위중등，기중CK적양성솔위80.95%고우기타각조적36.59%、5.00%、0.00%。경도、중도、중도골격기손상가사득CK적함량체（876±572）、（9875±3420）、（20341±4597）U/L명현고우무손상적정상인，이상차이유통계학의의（P<0.05）。결론골격기손상、심기、급간세포손상성질병도능도치혈청중전안산매급기산격매적변화。
Objective To analyze and explore the diagnostic significance of determination of serum transaminase and creatine ki-nase in patients with skeletal muscle disease. Methods The clinical data of 123 patients who had elevated levels of serum transaminase and creatine kinase detected in our hospital from September 1, 2012 to September 1, 2013 were sorted out and ana-lyzed. And 40 cases of healthy persons were selected as the control group. The clinical specimens of the 163 cases were divided into four groups, the skeletal muscle injury group (41 cases), the myocardial injury group (42 cases), liver cell injury group (40 cases) and the healthy control group (40 cases) group. The levels of serum transaminase and creatine kinase of the 163 cases were detected, respectively. Results The change of ALT of the myocardial injury group was the biggest, the positive rate was 73.16%, it was significantly higher than the positive rate of other three groups, 39.02%, 45.00%, 0.00%; the change of ALT content of the liver cell injury group was the biggest, the positive rate was 80.00%, which was obviously higher than that of the other groups, 31.70%, 28.57%, 0.00%; the change of AST, ALT, CK of the skeletal muscle injury group was relatively moderate, the positive rate of CK was 80.95%, which was higher than that of other groups, 36.59%, 5.00%, 0.00%. Mild, moderate, and severe skeletal muscle injury could make the content of CK reach (876 572), (9875 3420), (20341 4597) U/L, which was significantly higher than that in normal subjects without injury, the differences were statistically significant (P<0.05). Conclusion The skeletal muscle in-jury, myocardial injury and liver cell injury diseases can lead to the changes of serum transaminase and creatine kinase.
