CAJ | 학술논문

规律性耐力运动对收缩器官（骨骼肌）及远隔器官（心脏、脑、肝脏、脂肪等）均有健康促进效应。在骨骼肌中，运动通过调控PPARδ、AMPK、SIRT1及PGC-1α等一系列信号通路促进骨骼肌重塑。此外，收缩的骨骼肌合成“运动因子”（如IL-6、BDNF、Irisin等）并以内分泌方式释放入血，扩散并作用于远隔器官，是运动防治多种慢性疾病的重要途径。上述信号通路及＂运动因子“成为开发”运动模拟＂药物的靶向。本综述中，我们讨论了运动促进健康的生物学靶位及“运动模拟”药物开发的研究进展。
규률성내력운동대수축기관（골격기）급원격기관（심장、뇌、간장、지방등）균유건강촉진효응。재골격기중，운동통과조공PPARδ、AMPK、SIRT1급PGC-1α등일계렬신호통로촉진골격기중소。차외，수축적골격기합성“운동인자”（여IL-6、BDNF、Irisin등）병이내분비방식석방입혈，확산병작용우원격기관，시운동방치다충만성질병적중요도경。상술신호통로급＂운동인자“성위개발”운동모의＂약물적파향。본종술중，아문토론료운동촉진건강적생물학파위급“운동모의”약물개발적연구진전。
Regularenduranceexercisepromotesfavorablestructureandmetabolismadaptationsincon-tracting organ (skeletal muscle)and "far-sited"organ (heart,brain,liver,adipose tissue).Exercise induced skeletal muscle remodeling by activating a series of signaling and transcriptional circuitry (e.g., PPARδ,AMPK,SIRT1 and PGC-1α).In addition,contracting skeletal muscle is an endocrine organ producing and releasing myokines (e.g.IL-6,BDNF and Irisin),which work in a hormone-like fash-ion,exerting specific endocrine effects on "far-sited"organ.It has been suggested that myokines may contribute to exercise-induced protection against several chronic disease.In this review,we discuss re-cent discoveries that raise the possibility of synthetically mimicking exercise with pathway-specific drugs to improve health.