CAJ | 학술논문

目的：探讨类风湿关节炎（ rheumatoid arthritis，RA）患者病情活动程度与血脂水平的关系。方法：收集2010年12月至2012年12月包头医学院第二附属医院确诊的140例RA患者，根据 DAS28分为 A组、B组及 C组。结果：处于活动期患者血清TG、LDL水平明显高于对照组（ P <0.01），HDL水平低于对照组（ P <0.01），活动期RA患者的ESR、C3、C4、CRP、抗CCP、RF、IgA、IgG、IgM、TNF-a高于非活动期。血清TG、LDL水平与ESR、CRP、TNF-a呈正相关，血清HDL与ESR、CRP、TNF-a呈负相关。结论：活动期的RA患者体内存在脂质代谢明显异常，除ESR、CRP外，血脂可能成为评价RA病情活动的指标，作为评价类风湿关节炎疾病严重程度的指标之一。
목적：탐토류풍습관절염（ rheumatoid arthritis，RA）환자병정활동정도여혈지수평적관계。방법：수집2010년12월지2012년12월포두의학원제이부속의원학진적140례RA환자，근거 DAS28분위 A조、B조급 C조。결과：처우활동기환자혈청TG、LDL수평명현고우대조조（ P <0.01），HDL수평저우대조조（ P <0.01），활동기RA환자적ESR、C3、C4、CRP、항CCP、RF、IgA、IgG、IgM、TNF-a고우비활동기。혈청TG、LDL수평여ESR、CRP、TNF-a정정상관，혈청HDL여ESR、CRP、TNF-a정부상관。결론：활동기적RA환자체내존재지질대사명현이상，제ESR、CRP외，혈지가능성위평개RA병정활동적지표，작위평개류풍습관절염질병엄중정도적지표지일。
ObjectiVe:To inVestigate the relationship between disease actiVities and the serum lipid leVel in patients with rheumatoid arthritis( RA). Methods:140 cases of RA,diagnosed from December 2010 to December 2012 in the Second Affilia-ted Hospital of Baotou Medical College,were diVided into group A,group B and group C according to DAS28. ResuIts:The leV-el of serum TG and LDL in RA patients at actiVe phase of disease was significantly higher than that in the control group( P <0. 01),with HDL leVel lower than that in the control group( P <0. 01). The leVels of ESR,C4,CRP,C,anti-CCP,RF, IgA,IgM,TNF-a,IgG,at the actiVe phase in RA patients were higher than those at inactiVe phase. The leVels of Serum TG and LDL were positiVely correlated with those of ESR,CRP,TNF-a,and serum HDL leVel was negatiVely correlated with that of ESR,CRP,TNF-a. ConcIusion:Lipid metabolism is remarkably abnormal in RA patients at actiVe phase and the blood lip-id,apart from ESR and CRP,may become an eValuation indeX for the actiVities of RA and one of the eValuation indeXes for the seVerity of rheumatoid arthritis as well.