包头医学院学报
包頭醫學院學報
포두의학원학보
JOURNAL OF BAOTOU MEDICAL COLLEGE
2014年
4期
41-43
,共3页
甲硫腺苷磷酸化酶%单核苷酸多态性%缺血性卒中
甲硫腺苷燐痠化酶%單覈苷痠多態性%缺血性卒中
갑류선감린산화매%단핵감산다태성%결혈성졸중
Methylthioadenosine phosphorylase%Single nucleotide polymorphism( SNP)%Ischemic stroke
目的：探讨甲硫腺苷磷酸化酶（ Methylthioadenonine Phosphorylase，MTAP）基因多态性rs3802392与缺血性卒中的相关性。方法：采用聚合酶链式反应和限制性片段长度多态性（ PCR-RFLP ）方法对273例缺血性卒中患者和344例健康人的 rs3802392进行基因分型，并用 Logistic 回归方法分析其与缺血性卒中的关系。结果：MTAP 基因rs3802392基因型和等位基因频率在病例组和对照组的分布差异有统计学意义，MTAP基因rs3802392位点GA+GG基因型是缺血性卒中发病的独立危险因素。结论：MTAP基因rs3802392可能在缺血性卒中的发病中起一定作用。
目的：探討甲硫腺苷燐痠化酶（ Methylthioadenonine Phosphorylase，MTAP）基因多態性rs3802392與缺血性卒中的相關性。方法：採用聚閤酶鏈式反應和限製性片段長度多態性（ PCR-RFLP ）方法對273例缺血性卒中患者和344例健康人的 rs3802392進行基因分型，併用 Logistic 迴歸方法分析其與缺血性卒中的關繫。結果：MTAP 基因rs3802392基因型和等位基因頻率在病例組和對照組的分佈差異有統計學意義，MTAP基因rs3802392位點GA+GG基因型是缺血性卒中髮病的獨立危險因素。結論：MTAP基因rs3802392可能在缺血性卒中的髮病中起一定作用。
목적：탐토갑류선감린산화매（ Methylthioadenonine Phosphorylase，MTAP）기인다태성rs3802392여결혈성졸중적상관성。방법：채용취합매련식반응화한제성편단장도다태성（ PCR-RFLP ）방법대273례결혈성졸중환자화344례건강인적 rs3802392진행기인분형，병용 Logistic 회귀방법분석기여결혈성졸중적관계。결과：MTAP 기인rs3802392기인형화등위기인빈솔재병례조화대조조적분포차이유통계학의의，MTAP기인rs3802392위점GA+GG기인형시결혈성졸중발병적독립위험인소。결론：MTAP기인rs3802392가능재결혈성졸중적발병중기일정작용。
ObjectiVe:To inVestigate the relationship between single nucleotide polymorphism( SNP)rs3802392 in methyl-thioadenosine phosphorylase( MTAP)gene and ischemic stroke. Methods:SNP rs3802392 was genotyped among 273 patients with ischemic stroke and 344 normals as control group by polymorphism chain reaction( PCR)and restriction fragment length pol-ymorphism( RFLP)method. And the association of rs3802392 with ischemic stroke was analyzed using Logistic regression. Re-suIts:The significant differences in allele and genotype frequencies were detected between the case group and the control group, and GA+GG genotype was the independent risk factor for ischemic stroke. ConcIusion:SNP rs3802392 in MTAP gene may play a role in the deVelopment of ischemic stroke.
