CAJ | 학술논문

目的：探讨氯氰菊酯对小鼠小脑组织氧化应激的影响。方法：将40只昆明种小鼠随机分为氯氰菊酯（ cypermethrin，CYP）5 mg/kg组、10 mg/kg组、20 mg/kg组及双蒸水对照组，连续3周经口灌胃染毒后观察鼠小脑脏器系数，同时检测鼠小脑组织丙二醛（ Malonaldehyde，MDA）含量、谷胱甘肽过氧化物酶（ Glutathione PeroXidase，GSH-PX）、总超氧化物歧化酶（ Total SuperoXide Dismutase，T-SOD）、过氧化氢酶（ Catalase，CAT）活性。结果：各剂量染毒组小鼠小脑脏器系数与对照组比较差异具有统计学意义（ P <0.05）；各剂量染毒组小鼠小脑组织MDA含量升高，与对照组比较差异具有统计学意义（ P <0.05）；各剂量染毒组小鼠小脑组织GSH-PX、T-SOD、CAT活性降低，与对照组比较差异具有统计学意义（ P <0.05）。结论：氯氰菊酯可以引起小鼠小脑组织的氧化损伤。
목적：탐토록청국지대소서소뇌조직양화응격적영향。방법：장40지곤명충소서수궤분위록청국지（ cypermethrin，CYP）5 mg/kg조、10 mg/kg조、20 mg/kg조급쌍증수대조조，련속3주경구관위염독후관찰서소뇌장기계수，동시검측서소뇌조직병이철（ Malonaldehyde，MDA）함량、곡광감태과양화물매（ Glutathione PeroXidase，GSH-PX）、총초양화물기화매（ Total SuperoXide Dismutase，T-SOD）、과양화경매（ Catalase，CAT）활성。결과：각제량염독조소서소뇌장기계수여대조조비교차이구유통계학의의（ P <0.05）；각제량염독조소서소뇌조직MDA함량승고，여대조조비교차이구유통계학의의（ P <0.05）；각제량염독조소서소뇌조직GSH-PX、T-SOD、CAT활성강저，여대조조비교차이구유통계학의의（ P <0.05）。결론：록청국지가이인기소서소뇌조직적양화손상。
ObjectiVe:To eXplore the effects of cypermethrin on oXidatiVe stress of cerebellar tissues in male mice. Meth-ods:A total of 40 Kunming mice were randomly diVided into four groups:namely,the cypermethrin( CYP)5 mg/kg group,the CYP 10 mg/kg group,the CYP 20 mg/kg group and the control group,with different doses of CYP administered to mice by ga-Vage consecutiVely for three weeks( once daily). Three weeks after the administration,the cerebellum Viscera indeX was ob-serVed,the content of malondialdehyde( MDA)was determined,and the actiVities of glutathione peroXidase( Gsh-pX),total superoXide dismutase( T-SOD)and catalase( CAT)in mice brains were measured. ResuIts:There was a significant difference in the cerebellum Viscera indeX between Various CYP dose groups and the control group( P<0. 05). There was an increase in the content of MDA in all CYP group of different doses( P<0. 05). There was an decrease in the actiVities of GSH-PX,T-SOD and CAT in all the groups of different doses( P<0. 05). ConcIusion:Cypermethrin can bring about the oXidatiVe damage of cerebellar tissue in mice.