CAJ | 학술논문

目的：采用多种方法对高Hcy水平的脑卒中患者进行干预，探讨目前治疗伴有高Hcy血症脑卒中的适合方法。方法：把研究对象分脑梗死组（A组）260例，脑出血组（B组）100例，对照组（C组）200例，测定其Hcy等指标水平。把A、B组伴高Hcy血症的患者随机分为常规治疗组（a组）、甲钴胺组（b组）及针灸康复组（c组），在半个月后及6个月后再次检测Hcy水平并进行神经缺损功能评分。结果：A和B组的Hcy水平与C组相比显著升高(P<0.01)。b、c组与a组在治疗半个月及6个月后降低血Hcy水平方面比较差异有显著性(P<0.01)。三组神经功能缺损程度在治疗6个月后a组与b、c组比较有显著统计学意义。结论：高Hcy血症是脑卒中的独立危险因素，甲钴胺及针灸康复均能降低Hcy水平，可以改善脑卒中神经功能缺损状况。
목적：채용다충방법대고Hcy수평적뇌졸중환자진행간예，탐토목전치료반유고Hcy혈증뇌졸중적괄합방법。방법：파연구대상분뇌경사조（A조）260례，뇌출혈조（B조）100례，대조조（C조）200례，측정기Hcy등지표수평。파A、B조반고Hcy혈증적환자수궤분위상규치료조（a조）、갑고알조（b조）급침구강복조（c조），재반개월후급6개월후재차검측Hcy수평병진행신경결손공능평분。결과：A화B조적Hcy수평여C조상비현저승고(P<0.01)。b、c조여a조재치료반개월급6개월후강저혈Hcy수평방면비교차이유현저성(P<0.01)。삼조신경공능결손정도재치료6개월후a조여b、c조비교유현저통계학의의。결론：고Hcy혈증시뇌졸중적독립위험인소，갑고알급침구강복균능강저Hcy수평，가이개선뇌졸중신경공능결손상황。
Objective: To explore the appropriate treatment for patients with cerebral stroke accompanied by hyperhomocysteinemia by taking different intervention measures. Methods: 260 cases were the cerebral infarction group(group A )and 100 cases the cerebral hemorrhage group(group B);besides, 200 non-stroke patients were chosen as the control group(group C). The levels of Hcy of the three groups were respectively detected. patients with high Hcy, were randomly divided into the conventional therapy group (group a), the mecobalamin group (group b) and the acupuncture rehabilitation group (group c) and receive their respective treatments;half a month later and half a year later, the Hcy of blood plasma in the three groups was detected and the deficit of neurological function was assessed before and after the therapy in each group. Results:Compared with the group C, the Hcy content of the group A or the group B was obvious high, which was of statistical significance (P<0.01). Concentration of Hcy in the group b and the group c declined obviously half a month or half a year after treatment, while no conspicuous decline appeared in the Hcy concentration of the group a; therefore, in terms of lowering the Hcy concentration, comparing the two former groups with the group a, the difference was of statistical significance (P<0.01). The difference in the deficit of neurological function among the three groups half a year after treatment was distinctly of statistical significance. Conclusion: Hyperhomocysteinemia is an independent risk factor in the cerebral stroke; the mecobalamin and acupuncture rehabilitation treatments can reduce the Hcy level and in the long term ameliorate the condition of deficits of neurological function for patients with cerebral stroke.