CAJ | 학술논문

目的：探讨速尿对131I治疗分化型甲状腺癌（D T C）效果的影响。方法：将符合入选标准的32例DTC术后患者随机分为速尿组与对照组，速尿组给予131I 0.37Mbq同时口服速尿30mg，每天一次，连用4天，对照组按照常规给予131I 0.37Mbq，两组患者分别于24、48、96h测量摄碘率和计算有效半衰期、24h尿碘量。结果：速尿组用药前、后相比24h测量摄碘率增加（t=3.5，P＜0.05），有效半衰期无明显改变（t=0.96，P>0.05），速尿组与对照组24h测量131I摄碘率和24h尿碘排出量比较差异有统计学意义（t=2.79 t=7.2，P＜0.05），有效半衰期差异无统计学意义（t=0.78，P>0.05）。结论：速尿能提高D T C患者术后残留甲状腺摄取131I功能，增加病灶辐射吸收剂量，从而对治疗效果有益，值得临床推广。
목적：탐토속뇨대131I치료분화형갑상선암（D T C）효과적영향。방법：장부합입선표준적32례DTC술후환자수궤분위속뇨조여대조조，속뇨조급여131I 0.37Mbq동시구복속뇨30mg，매천일차，련용4천，대조조안조상규급여131I 0.37Mbq，량조환자분별우24、48、96h측량섭전솔화계산유효반쇠기、24h뇨전량。결과：속뇨조용약전、후상비24h측량섭전솔증가（t=3.5，P＜0.05），유효반쇠기무명현개변（t=0.96，P>0.05），속뇨조여대조조24h측량131I섭전솔화24h뇨전배출량비교차이유통계학의의（t=2.79 t=7.2，P＜0.05），유효반쇠기차이무통계학의의（t=0.78，P>0.05）。결론：속뇨능제고D T C환자술후잔류갑상선섭취131I공능，증가병조복사흡수제량，종이대치료효과유익，치득림상추엄。
Objective:To investigate the effects of furosemide for efifcacy of 131I for differentiated thyroid carcinoma (DTC) . Methods: 32 cases of DTC patients matched with the inclusion criteria were randomly divided into furosemide group and control group.Patients of furosemide group were given 131I 0.37mbq and oral furosemide 30mg once a day for four days according to the conventional control group given 131I 0.37mbq. Two groups of patients will be measured the rate of iodine intake and calculated the effective half-life and 24-hour urine of iodine every 24,48 and 96 hours. Results:In furosemide group,24-hour rate of iodine intake measurements between before treatment and after treatmemt (t=3.5,P<0.05),while the effective half-life did not change signiifcantly (t=0.96,P>0.05). Compare to control group,24-hour rate of iodine intake and 24-hour excluded volume of urinary iodine of furosemide group had signiifcant difference (t=2.79 t=7.2,P<0.05).while the effective half-life did not change signiifcantly (t=0.78,P>0.05). Conclusion:Furosemide can improve iodine intake function of postoperative residual thyroid of DTC patients,which is beneifcial to treatment effect and clinical promotion.