CAJ | 학술논문

为了研究急性铅中毒对小鼠睾丸病理变化的影响，通过对小鼠饲喂含有醋酸铅的去离子水建立铅负荷小鼠模型.处理10 d后取材，分析体质量、睾丸指数和睾丸病理剖检变化.结果显示：与对照组相比，铅中毒组小鼠体质量无明显变化，睾丸指数降低，且差异显著（P＜0.05）；小鼠睾丸中支持细胞、生精细胞和间质细胞数量减少.铅对小鼠睾丸具有显著损害作用，从而影响小鼠的生殖健康.
위료연구급성연중독대소서고환병리변화적영향，통과대소서사위함유작산연적거리자수건립연부하소서모형.처리10 d후취재，분석체질량、고환지수화고환병리부검변화.결과현시：여대조조상비，연중독조소서체질량무명현변화，고환지수강저，차차이현저（P＜0.05）；소서고환중지지세포、생정세포화간질세포수량감소.연대소서고환구유현저손해작용，종이영향소서적생식건강.
To investigate the effect of acute lead poisoning on pathological changes in mice testis,mice were orally administered with lead acetate for 10 days to establish a lead poisoning mice model.After 10 days,some indexes,such as body weight,testis index,necropsy and histopathology,were analyzed.The results showed that the body weight change of mice was not relevant significantly to the dosage of lead acetate.Compared with the control group,the difference of testis relative index in dosage group was significant (P<0.05).The amount of sertoli cells,germ cells and Leydig’s cells in mice tesis was decreased.The results suggested that lead could damage mice testis significantly and then affect the reproductive health of mice.