CAJ | 학술논문

目的：观察卷柏黄酮对小鼠中枢神经系统的影响。方法：采用行为学法观察高、中、低3个剂量卷柏黄酮作用小鼠后对小鼠自主活动、协调运动及阈下剂量戊巴比妥钠催眠作用的影响。结果：与空白对照组相比，3个剂量组小鼠的自主活动次数有所减少，尤以高剂量卷柏黄酮组减少最为明显（F组间＝9．819，F时间＝4．480，F交互＝2．489，P均＜0．001）；与空白对照组相比，中、低剂量卷柏黄酮对小鼠的协调运动无明显影响，高剂量卷柏黄酮可明显降低小鼠的协调运动能力（F组间＝93．265，F时间＝287．416，F交互＝88．062，P均＜0．001）；与空白对照组相比，3种剂量的卷柏黄酮对小鼠阈下剂量戊巴比妥钠睡眠持续时间无明显影响（P＞0．05）。结论：高剂量卷柏黄酮对小鼠有一定的镇静作用。
목적：관찰권백황동대소서중추신경계통적영향。방법：채용행위학법관찰고、중、저3개제량권백황동작용소서후대소서자주활동、협조운동급역하제량무파비타납최면작용적영향。결과：여공백대조조상비，3개제량조소서적자주활동차수유소감소，우이고제량권백황동조감소최위명현（F조간＝9．819，F시간＝4．480，F교호＝2．489，P균＜0．001）；여공백대조조상비，중、저제량권백황동대소서적협조운동무명현영향，고제량권백황동가명현강저소서적협조운동능력（F조간＝93．265，F시간＝287．416，F교호＝88．062，P균＜0．001）；여공백대조조상비，3충제량적권백황동대소서역하제량무파비타납수면지속시간무명현영향（P＞0．05）。결론：고제량권백황동대소서유일정적진정작용。
Aim:To study the effect of selaginella Tamariscina ( Beauv .) spring flavonoids on mouse central nervous system.Methods:The mice freedom movement , coordinate motion and harmonious movement drop asleep persistent times after giving pentobarbitale sodium were observed by methods animal behaviour observation .Results:The mice freedom movement can be reduce with the time in the three doses and especially for the high dose , it has a significant decrease in the mice freedom movement(Fgroup =9.819,Ftime =4.480,Fintercross =2.489, P<0.01).Compared with the normal group, there was no effect on coordinate motion in the middle and low dose , while a significant decrease in the high dose group (Fgroup =93.265,Ftime =287.416, Fintercross =88.062,P<0.01).Selaginella Tamariscina at these three dose has no effect on harmonious movement drop asleep persistent times after giving pentobarbitale sodium compared with the normal group (P>0.05).Conclusion:Selaginella Tamariscina(Beauv.) spring flavonoids of high dose has a sedation in mice .