CAJ | 학술논문

目的：探讨二氧化铈（ CeO2）纳米颗粒对大鼠缺血再灌注损伤心肌的保护作用。方法：SD大鼠24只，随机分为模型组、假手术组、CeO2纳米颗粒组，每组8只，除假手术组外均制作大鼠心肌缺血再灌注模型。分别测定心肌组织中超氧化物歧化酶（ SOD）、过氧化氢酶（ CAT）、乳酸脱氢酶（ LDH）、肌酸激酶同工酶（ CK-MB）活性和丙二醛（ MDA）含量，同时观察心肌组织病理学改变。结果：与假手术组相比，模型组SOD、CAT、LDH、CK-MB活性下降， MDA含量升高（P均＜0．05）；与模型组相比，CeO2纳米颗粒组SOD、CAT、LDH、CK-MB活性升高，MDA含量降低（P均＜0．05）。结论：CeO2纳米颗粒能减轻大鼠心肌的缺血再灌注损伤，具有良好的心肌保护作用。
목적：탐토이양화시（ CeO2）납미과립대대서결혈재관주손상심기적보호작용。방법：SD대서24지，수궤분위모형조、가수술조、CeO2납미과립조，매조8지，제가수술조외균제작대서심기결혈재관주모형。분별측정심기조직중초양화물기화매（ SOD）、과양화경매（ CAT）、유산탈경매（ LDH）、기산격매동공매（ CK-MB）활성화병이철（ MDA）함량，동시관찰심기조직병이학개변。결과：여가수술조상비，모형조SOD、CAT、LDH、CK-MB활성하강， MDA함량승고（P균＜0．05）；여모형조상비，CeO2납미과립조SOD、CAT、LDH、CK-MB활성승고，MDA함량강저（P균＜0．05）。결론：CeO2납미과립능감경대서심기적결혈재관주손상，구유량호적심기보호작용。
Aim:To investigate the protective effects of CeO 2 nanoparticles on myocardial ischemic reperfusion injury in rats.Methods:Twenty-four male SD rats were randomly divided into three groups:model group ,sham operation group and CeO2 group(8 in each group).The myocardial ischemic reperfusion model had been established successfully .The activities of SOD,CAT,LDH,CK-MB and the content of MDA were detected .The morphology of myocardium was observed with light microscope.Results:The activities of SOD,CAT,LDH,and CK-MB decreased while the content of MDA increased in model group in comparison with sham operation group (P<0.05).Compared with the model group,the activities of SOD,CAT, LDH,and CK-MB in CeO2 group increased significantly,while the content of MDA decreased(P<0.05).Conclusion:The CeO2 nanoparticles could protect the myocardium of rats from ischemic reperfusion injury .