郑州大学学报(医学版)
鄭州大學學報(醫學版)
정주대학학보(의학판)
JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES)
2014年
5期
608-611
,共4页
李娜%杨薇%王新帅%孙佳春%孔国强%单探幽%贾瑞诺%原翔%刘刚%高社干
李娜%楊薇%王新帥%孫佳春%孔國彊%單探幽%賈瑞諾%原翔%劉剛%高社榦
리나%양미%왕신수%손가춘%공국강%단탐유%가서낙%원상%류강%고사간
食管鳞状细胞癌%鳞癌扩增基因1%预后
食管鱗狀細胞癌%鱗癌擴增基因1%預後
식관린상세포암%린암확증기인1%예후
esophageal squamous cell carcinoma%GASC1%prognosis
目的:探讨鳞癌扩增基因1(GASC1)在食管鳞状细胞癌(ESCC)组织中的表达及临床意义。方法:采用免疫组化SP法检测82例ESCC组织及相应癌旁正常食管黏膜组织(距离癌组织5 cm以上)中GASC1的表达;术后随访2 a,对GASC1阴性和阳性表达的ESCC患者进行生存分析。结果:ESCC和配对癌旁正常食管黏膜组织中GASC1蛋白的阳性表达率分别为51.2%、42.7%,两种组织中GASC1蛋白的阳性表达率差异无统计学意义(χ2=1.895,P=0.169),但具有一致性(Kappa=0.538,P<0.001)。在T3期、中低分化、有淋巴结转移和临床晚期(Ⅲ期)等恶性程度较高的ESCC组织中GASC1蛋白阳性表达率高于T1及T2期、高分化、无淋巴结转移和临床早期(Ⅰ、Ⅱ期)者(χ2=5.030、6.057、8.995、7.045,P<0.05)。 GASC1阳性组和阴性组ESCC患者术后2 a Kaplan-Meier生存曲线差异有统计学意义(χ2=5.688,P=0.040),2 a生存率分别为65.8%和86.4%。结论:GASC1表达与ESCC恶性表型、侵袭能力及预后有关。
目的:探討鱗癌擴增基因1(GASC1)在食管鱗狀細胞癌(ESCC)組織中的錶達及臨床意義。方法:採用免疫組化SP法檢測82例ESCC組織及相應癌徬正常食管黏膜組織(距離癌組織5 cm以上)中GASC1的錶達;術後隨訪2 a,對GASC1陰性和暘性錶達的ESCC患者進行生存分析。結果:ESCC和配對癌徬正常食管黏膜組織中GASC1蛋白的暘性錶達率分彆為51.2%、42.7%,兩種組織中GASC1蛋白的暘性錶達率差異無統計學意義(χ2=1.895,P=0.169),但具有一緻性(Kappa=0.538,P<0.001)。在T3期、中低分化、有淋巴結轉移和臨床晚期(Ⅲ期)等噁性程度較高的ESCC組織中GASC1蛋白暘性錶達率高于T1及T2期、高分化、無淋巴結轉移和臨床早期(Ⅰ、Ⅱ期)者(χ2=5.030、6.057、8.995、7.045,P<0.05)。 GASC1暘性組和陰性組ESCC患者術後2 a Kaplan-Meier生存麯線差異有統計學意義(χ2=5.688,P=0.040),2 a生存率分彆為65.8%和86.4%。結論:GASC1錶達與ESCC噁性錶型、侵襲能力及預後有關。
목적:탐토린암확증기인1(GASC1)재식관린상세포암(ESCC)조직중적표체급림상의의。방법:채용면역조화SP법검측82례ESCC조직급상응암방정상식관점막조직(거리암조직5 cm이상)중GASC1적표체;술후수방2 a,대GASC1음성화양성표체적ESCC환자진행생존분석。결과:ESCC화배대암방정상식관점막조직중GASC1단백적양성표체솔분별위51.2%、42.7%,량충조직중GASC1단백적양성표체솔차이무통계학의의(χ2=1.895,P=0.169),단구유일치성(Kappa=0.538,P<0.001)。재T3기、중저분화、유림파결전이화림상만기(Ⅲ기)등악성정도교고적ESCC조직중GASC1단백양성표체솔고우T1급T2기、고분화、무림파결전이화림상조기(Ⅰ、Ⅱ기)자(χ2=5.030、6.057、8.995、7.045,P<0.05)。 GASC1양성조화음성조ESCC환자술후2 a Kaplan-Meier생존곡선차이유통계학의의(χ2=5.688,P=0.040),2 a생존솔분별위65.8%화86.4%。결론:GASC1표체여ESCC악성표형、침습능력급예후유관。
Aim:To detect the expression of gene amplified in squamous cell carcinoma 1( GASC1) protein in esopha-geal squamous cell carcinoma ( ESCC) tissue.Methods:A total of 82 primary ESCC specimens and adjacent normal muco-sa tissue were collected to examine the GASC 1 expression by immunohistochemistry .The patients obtained two-year follow-up,and Kaplan-Meier survival analysis was conducted .Results:GASC1 positive expression rate was 51.2%in ESCC tissue and 42.7%in adjacent normal mucosa tissue,there were no difference(χ2 =1.895,P=0.169),but consistency between ESCC and adjacent normal mucosa tissue(Kappa=0.538,P<0.001).GASC1 expression was higher in tissues with T3, median and low degree of differentiation ,lymph node metastasis and at clinical Ⅲ stage than those in tissues with T 1 and T2,high degree of differentiation ,no lymph node metastasis and at clinical ⅠandⅡstage (χ2 =5.030,6.057,8.995, 7.045,P<0.05).The Kaplan-Meier survival curves of patients with GASC1 positive expression and with GASC1 negative expression had significant difference (χ2 =5.688,P=0.040),the two-year survival rate was 65.8% and 86.4%,respec-tively.Conc lusion:GASC1 may be associated with esophageal malignant phenotype ,invasive ability and prognosis .