CAJ | 학술논문

目的：探讨正常饮食和高脂肪饮食对小鼠体重、血糖、葡萄糖耐受、血脂、脂肪肝的影响。方法雄性C57BL/6小鼠随机分为MD10％和MD45％脂肪含量饲料组，喂养3个月，检测动物体重、血糖、葡萄糖耐受、血脂，以及主要脏器重量及肝脏脂质含量。结果与正常组（ MD10％脂肪含量）相比，高脂组（ MD45％脂肪含量）动物体重显著增加，出现明显的糖耐量异常和血脂水平升高，同时伴有肝脏脂质含量增加。结论高脂饮食对非酒精性脂肪肝有较强的诱导作用。
목적：탐토정상음식화고지방음식대소서체중、혈당、포도당내수、혈지、지방간적영향。방법웅성C57BL/6소서수궤분위MD10％화MD45％지방함량사료조，위양3개월，검측동물체중、혈당、포도당내수、혈지，이급주요장기중량급간장지질함량。결과여정상조（ MD10％지방함량）상비，고지조（ MD45％지방함량）동물체중현저증가，출현명현적당내량이상화혈지수평승고，동시반유간장지질함량증가。결론고지음식대비주정성지방간유교강적유도작용。
Objective To examine potential effect of normal chow /high-fat diet on body weight,blood glucose,and glu-cose tolerance,serum total cholesterol(TC) and triglycerides(TG) concentrations,fatty liver in mice.Methods Males C57BL/6 mice were randomly divided into two groups and fed with 10%fat content diet ( MD10%fat),and 45% fat content(MD 45%fat) for 12 weeks respectively .Body and organ weight ,blood glucose and glucose tolerance ,and serum TC and TG concen-trations,liver TC and TG contents were measured.Results Compared with the controls(MD10% fat),the animals fed with high-fat diet(MD 45%fat) showed a significant increase in body weight ,blood glucose levels,glucose intolerance,serum TC and TG concentrations,hepatic TC and TG contents.Conclusion High-fat diet(MD 45% fat) can produce most phenotypes of nonalcoholic fatty liver disease ( NAFLD) .