CAJ | 학술논문

黑色素瘤特异性抗原作为肿瘤睾丸抗原家族成员之一，通过抑制维甲酸受体信号通路，阻碍调控细胞生长、分化的转录因子，促进肿瘤的形成。其在实体肿瘤及血液恶性肿瘤中均有表达，因此多用于肿瘤的诊断、转移监测及免疫细胞治疗。
흑색소류특이성항원작위종류고환항원가족성원지일，통과억제유갑산수체신호통로，조애조공세포생장、분화적전록인자，촉진종류적형성。기재실체종류급혈액악성종류중균유표체，인차다용우종류적진단、전이감측급면역세포치료。
As a member of the family of cancer-testis antigen,preferentially expressed antigen of mela-noma(Prame)can improve the proliferation of tumor via inhibiting the retinoic acid receptor signal path and impeding the transcription factor which is a wide range of physiological processes in development and differentia-tion of tumor cells. Prame expresses in solid tumors and hematological malignancies,which is widely used for tumor diagnosis,monitoring of tumor metastasis and immunotherapy.