CAJ | 학술논문

人组织激肽释放酶（KLK）基因家族由15个高度保守的丝氨酸蛋白酶组成，是人类基因组中最大的不间断排列的蛋白酶基因簇。许多 KLK 家族成员有望成为肿瘤诊断和预后的标志物。研究发现卵巢癌组织 KLK2-11、KLK13-15均异常表达，多种 KLK 有潜在的诊断和预后价值。
인조직격태석방매（KLK）기인가족유15개고도보수적사안산단백매조성，시인류기인조중최대적불간단배렬적단백매기인족。허다 KLK 가족성원유망성위종류진단화예후적표지물。연구발현란소암조직 KLK2-11、KLK13-15균이상표체，다충 KLK 유잠재적진단화예후개치。
The human tissue kallikrein(KLK)gene family consists of 15 highly conservative serine pro-teases,which is the largest uninterrupted cluster of protease genes in the human genome. Several members of the family are expected to be markers for tumor diagnosis and prognosis. Studies find that the expressions of KLK2-11 and KLK13-15 are abnormal,and the majority of KLKs have potential diagnostic and prognostic values.