中国药师
中國藥師
중국약사
CHINA PHARMACIST
2014年
9期
1503-1505
,共3页
盐酸吡格列酮%流化床%微丸%缓释%包衣
鹽痠吡格列酮%流化床%微汍%緩釋%包衣
염산필격렬동%류화상%미환%완석%포의
Pioglitazone hydrochloride%Fluidized-bed%Pellets%Sustained-release%Coating
目的：制备盐酸吡格列酮缓释微丸胶囊并考察其体外释放特性。方法：底喷式流化床包衣制备盐酸吡格列酮缓释微丸，通过正交设计优化处方。结果：该方法简单易操作，所选处方工艺重复性良好，所制备微丸具有明显缓释作用。结论：该包衣处方及制备工艺简便可控，缓释微丸稳定性良好。
目的：製備鹽痠吡格列酮緩釋微汍膠囊併攷察其體外釋放特性。方法：底噴式流化床包衣製備鹽痠吡格列酮緩釋微汍，通過正交設計優化處方。結果：該方法簡單易操作，所選處方工藝重複性良好，所製備微汍具有明顯緩釋作用。結論：該包衣處方及製備工藝簡便可控，緩釋微汍穩定性良好。
목적：제비염산필격렬동완석미환효낭병고찰기체외석방특성。방법：저분식류화상포의제비염산필격렬동완석미환，통과정교설계우화처방。결과：해방법간단역조작，소선처방공예중복성량호，소제비미환구유명현완석작용。결론：해포의처방급제비공예간편가공，완석미환은정성량호。
Objective:To prepare pioglitazone hydrochloride ( PGH) sustained-release pellet capsules and study the in vitro disso-lution. Methods:The preparation was prepared with a bottom spray fluidized bed, and the formula and technology were optimized by orthogonal test. Results:The method was simple and easy to operate, the reproducibility of the formula and technology was good, and the pellets had obvious sustained-release property. Conclusion:The formula and technology are easy and controllable, and the stability of sustained release pellets is good.
