CAJ | 학술논문

目的：建立金鸡胶囊中3个主要生物碱的一测多评含量测定方法。方法：以巴马汀为内参物,建立巴马汀与药根碱、小檗碱的相对校正因子,计算药根碱和小檗碱的含量,实现一测多评。采用外标法测定金鸡制剂中巴马汀、药根碱和小檗碱含量,Pearson相关系数法比较计算值和测定值的差异。结果：一测多评法的计算值和外标法测定值间无显著差异,试验所得的校正因子可信。结论：以外标法测定巴马汀,利用相对校正因子实现对药根碱和小檗碱成分含量测定可行。
목적：건립금계효낭중3개주요생물감적일측다평함량측정방법。방법：이파마정위내삼물,건립파마정여약근감、소벽감적상대교정인자,계산약근감화소벽감적함량,실현일측다평。채용외표법측정금계제제중파마정、약근감화소벽감함량,Pearson상관계수법비교계산치화측정치적차이。결과：일측다평법적계산치화외표법측정치간무현저차이,시험소득적교정인자가신。결론：이외표법측정파마정,이용상대교정인자실현대약근감화소벽감성분함량측정가행。
Objective: To establish a quantitative analysis of multi-components by single marker ( QAMS ) for determining the three alkaloids in Jinji capsules. Methods:With the typical composition palmatine as the internal standard, the relative correction fac-tor ( RCF) between the palmatine and berberine or jateorhizine was respectively established, and the content of berberine and jateorhiz-ine was respectively calculated by QAMS. An external standard method was used to determine the three alkaloids, and the calculated values were compared with the estimated values by Pearson correlation coefficient. Results:There was no significant difference between the calculated values in QAMS and the estimated values in the external standard method, and the RCF was credible. Conclusion:The new method is feasible and accurate to evaluate the contents of the three alkaloids in Jinji capsules.