按摩与康复医学
按摩與康複醫學
안마여강복의학
Chinese Manipulation & Rehabilitation Medicine
2014年
9期
216-217
,共2页
佐剂性关节炎%IL-6%IL-1β%TNF-α%肿胀度%肿胀抑制率%大鼠模型
佐劑性關節炎%IL-6%IL-1β%TNF-α%腫脹度%腫脹抑製率%大鼠模型
좌제성관절염%IL-6%IL-1β%TNF-α%종창도%종창억제솔%대서모형
adjuvant arthritis%IL-6%IL-1%TNF-α%swelling degree%swelling inhibition rate%rat model
目的：研究芪冬颐心口服液对大鼠佐剂性关节炎（AA）的疗效及其可能机制。方法：50只SD大鼠随机分为正常组、模型组、高剂量组（20mL）、中剂量组（10mL）和低剂量组（5mL），给药后测量各组大鼠后足肿胀度及肿胀抑制率，Elisa法检测血清IL-6、IL-1β、TNF-α水平。结果：高剂量组、中剂量组和低剂量组左足跖体积较模型组明显减小（P<0.01）；高剂量组、中剂量组和低剂量组IL-6、IL-1β、TNF-α水平显著低于模型组（P<0.01）。结论：芪冬颐心口服液治疗AA大鼠有一定效果，其机制可能与降低血清IL-6、IL-1β、TNF-α水平有关。
目的：研究芪鼕頤心口服液對大鼠佐劑性關節炎（AA）的療效及其可能機製。方法：50隻SD大鼠隨機分為正常組、模型組、高劑量組（20mL）、中劑量組（10mL）和低劑量組（5mL），給藥後測量各組大鼠後足腫脹度及腫脹抑製率，Elisa法檢測血清IL-6、IL-1β、TNF-α水平。結果：高劑量組、中劑量組和低劑量組左足蹠體積較模型組明顯減小（P<0.01）；高劑量組、中劑量組和低劑量組IL-6、IL-1β、TNF-α水平顯著低于模型組（P<0.01）。結論：芪鼕頤心口服液治療AA大鼠有一定效果，其機製可能與降低血清IL-6、IL-1β、TNF-α水平有關。
목적：연구기동이심구복액대대서좌제성관절염（AA）적료효급기가능궤제。방법：50지SD대서수궤분위정상조、모형조、고제량조（20mL）、중제량조（10mL）화저제량조（5mL），급약후측량각조대서후족종창도급종창억제솔，Elisa법검측혈청IL-6、IL-1β、TNF-α수평。결과：고제량조、중제량조화저제량조좌족척체적교모형조명현감소（P<0.01）；고제량조、중제량조화저제량조IL-6、IL-1β、TNF-α수평현저저우모형조（P<0.01）。결론：기동이심구복액치료AA대서유일정효과，기궤제가능여강저혈청IL-6、IL-1β、TNF-α수평유관。
Objective:To study the effect and possible mechanism of Qidong Yixin oral liquid on rat adjuvant arthritis (AA). Methods:50 SD rats were randomly divided into normal group, model group, high-dose group (20mL), medial-dose group (10mL) and low-dose group (5mL), metapedes swelling degree and swelling inhibition rate of each group were measured after administration, with Elisa method for serum IL-6, IL-1β, TNF-αlev-el. Results:The left foot volume of high-dose group, medial-dose group and low-dose group were significantly smaller than that of model group (P<0.01);IL-6, IL-1β, TNF-αlevel of high-dose group, medial-dose group and low-dose group were all significantly lower than those of model group (P<0.01). Conclusion:Qidong Yixin oral liquid treating AA rats have a certain effect, the mechanism may be related to decrease serum IL-6, IL-1β, TNF-αlevel.
