CAJ | 학술논문

目的：探讨外周动静脉全自动换血术治疗新生儿重度高胆红素血症的疗效，以及并发症发生的危险因素。方法对37例符合换血指征的重度高胆红素血症患儿，采用全自动外周动静脉同步换血术治疗，比较换血前后血液中血清胆红素、白细胞、血红蛋白、血小板、血钾、血钙、pH值等变化情况。结果换血后总胆红素水平明显下降，差异有统计学意义(P＜0.01)；血红蛋白及血糖较换血前升高，差异有统计学意义(P＜0.05)；白细胞、血小板及血钙较换血前降低(P＜0.01)。胎龄≤32周、体重＜1500g、换血时患儿患病为并发症发生的危险因素(P＜0.05)。结论全自动动静脉换血疗法是治疗高胆红素血症的最迅速有效方法，操作简便、安全性高，值得临床推广应用。
목적：탐토외주동정맥전자동환혈술치료신생인중도고담홍소혈증적료효，이급병발증발생적위험인소。방법대37례부합환혈지정적중도고담홍소혈증환인，채용전자동외주동정맥동보환혈술치료，비교환혈전후혈액중혈청담홍소、백세포、혈홍단백、혈소판、혈갑、혈개、pH치등변화정황。결과환혈후총담홍소수평명현하강，차이유통계학의의(P＜0.01)；혈홍단백급혈당교환혈전승고，차이유통계학의의(P＜0.05)；백세포、혈소판급혈개교환혈전강저(P＜0.01)。태령≤32주、체중＜1500g、환혈시환인환병위병발증발생적위험인소(P＜0.05)。결론전자동동정맥환혈요법시치료고담홍소혈증적최신속유효방법，조작간편、안전성고，치득림상추엄응용。
Objective To investigate the effect of automated peripheral arteriovenous exchange transfusion for treatment of severe hyperbilirubinemia in neonates, and the potential risk factors of complications.Methods37 neonates with severe hyperbilirubinemia underwent automated peripheral arteriovenous exchange transfusion. The changes in the blood gasses, electrolytes and some biochemical indices after and before the treatment were compared, such as serum bilirubin, white blood cells, platelets, hemoglobin, kalium, calcium, pH, et al.Results After the exchange transfusion, the level of the total serum bilirubin decreased signiifcantly(P<0.01). The hemoglobin and the blood glucose increased signiifcantly(P<0.01). The white blood cells, platelets, and calcium decreased signiifcantly(P<0.01). The risk factors of complications were fetus less than 32 weeks, the birth weight less than 1 500 g, and the neonates sick during the exchange transfusion.Conclusion The treatment of neonatal hyperbilirubinemia by peripheral arteriovenous automatic synchronous exchange transfusion is reliable, effective, and easy to operate, which was worthy widely promoted in the clinical application.